Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study)

Ipilimumab 3mg per kg every 3 weeks for 4 doses

Nivolumab 1mg/kg every 3 weeks for 4 doses, then 480mg every 4 weeks.

The first dose of immunotherapy Must be given prior to the start of radiotherapy. One fraction at between 16 to 22 Gy or 24 to 30 Gy hypofractionated for larger lesions.

Any form of salvage therapy (surgery or radiotherapy) for intracranial disease progression, further disease control at any site, symptom control or treatment of cerebral haemorrhage or cerebral radionecrosis.