314
Participants
Start Date
December 27, 2017
Primary Completion Date
September 30, 2025
Study Completion Date
November 30, 2026
Atezolizumab
Atezolizumab is administered by IV on Day 1 of each 21 day cycle or on Days 1 and 15 of each 28 day cycle.
Cobimetinib
Cobimetinib is administered orally on Days 1-21 of a 28 day cycle.
RO6958688
"Cycle 1:~RO6958688 is administered by IV infusion on Days 1, 8, and 15 of a 21 day cycle at increasing dosage.~Subsequent cycles:~RO6958688 is administered by IV infusion on Days 1, 8, and 15 of a 21 day cycle."
Docetaxel
Docetaxel is administered by IV on Day 1 of each 21 day cycle.
CPI-444
CPI-444 is administered orally twice daily on Days 1- 21, of a 21 day cycle.
Pemetrexed
Pemetrexed is administered by IV on Day 1 of a 21 day cycle.
Carboplatin
Carboplatin is administered by IV on day 1 of the first 4 or 6 cycles out of a 21 day cycle.
Gemcitabine
Gemcitabine is administered by IV on Days 1 and 8 of the first 4 or 6 cycles out of a 21 day cycle.
Linagliptin
Linagliptin is administered orally once daily on Days 1 to 21 out of a 21 day cycle.
Tocilizumab
Tocilizumab is administered for the management of cytokine-release syndrome in the RO6958688-containing arms.
Ipatasertib
Ipatasertib will be administered orally once a day on Days 1-21 of each 28-day cycle.
Bevacizumab
Bevacizumab is administered by IV on Day 1 of each 21-day cycle.
Sacituzumab Govitecan
Sacituzumab Govitecan is administered by IV on Day 1 and 8 of each 21-day cycle.
Radiation
Radiotherapy up to 21 days
Evolocumab
Evolocumab is administered subcutaneously at a dose of 140 mg on Days 1 and 15 of each 28-day cycle.
Tiragolumab
Tiragolumab is administered on Day 1 of each 21 day cycle.
XL092
XL092 is administered orally once a day on Day 1 to Day 21 of a 21 day cycle.
Camonsertib
Camonsertib is administered orally on Days 1-3, Days 8-10 of a 21 day cycle.
Blacktown Hospital, Blacktown
Peter Mac Callum Cancer Center, East Melbourne
Columbia University Medical Center, New York
Taipei Veterans General Hospital, Taipei
Hopital de la Timone, Marseille
Christiana Care Health Services, Newark
Centre Georges Francois Leclerc, Dijon
Fundación Jimenez Díaz, Madrid
Hospital Universitario HM Sanchinarro-CIOCC, Madrid
Hospital Regional Universitario de Malaga, Málaga
Clínica Universidad de Navarra, Pamplona
Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse
CHU de Bordeaux - Groupe Hospitalier Saint-André - Hopital Saint-Andre, Bordeaux
Institut Régional du Cancer de Montpellier, Montpellier
SCRI Oncology Partners, Nashville
University Hospitals Case Medical Center, Cleveland
Institut De Cancerologie De L'Ouest, Saint-Herblain
Hospital Clinico Universitario de Valencia, Valencia
Centre Léon Bérard, Lyon
Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley, Las Vegas
Hospital Universitario La Paz, Madrid
Rambam Medical Center, Haifa
Rabin Medical Center, Petah Tikva
Chaim Sheba Medical Center, Ramat Gan
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Korea University Guro Hospital, Seoul
University of Ulsan College of Medicine - Asan Medical Center (AMC) - Asan Cancer Center (ACC), Songpa-gu
Hospital Universitari Vall d'Hebron, Barcelona
Barts Cancer Institute, London
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne
Royal Marsden Hospital, Sutton
Hoffmann-La Roche
INDUSTRY