A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

314

Participants

Timeline

Start Date

December 27, 2017

Primary Completion Date

September 30, 2025

Study Completion Date

November 30, 2026

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Atezolizumab

Atezolizumab is administered by IV on Day 1 of each 21 day cycle or on Days 1 and 15 of each 28 day cycle.

DRUG

Cobimetinib

Cobimetinib is administered orally on Days 1-21 of a 28 day cycle.

DRUG

RO6958688

"Cycle 1:~RO6958688 is administered by IV infusion on Days 1, 8, and 15 of a 21 day cycle at increasing dosage.~Subsequent cycles:~RO6958688 is administered by IV infusion on Days 1, 8, and 15 of a 21 day cycle."

DRUG

Docetaxel

Docetaxel is administered by IV on Day 1 of each 21 day cycle.

DRUG

CPI-444

CPI-444 is administered orally twice daily on Days 1- 21, of a 21 day cycle.

DRUG

Pemetrexed

Pemetrexed is administered by IV on Day 1 of a 21 day cycle.

DRUG

Carboplatin

Carboplatin is administered by IV on day 1 of the first 4 or 6 cycles out of a 21 day cycle.

DRUG

Gemcitabine

Gemcitabine is administered by IV on Days 1 and 8 of the first 4 or 6 cycles out of a 21 day cycle.

DRUG

Linagliptin

Linagliptin is administered orally once daily on Days 1 to 21 out of a 21 day cycle.

DRUG

Tocilizumab

Tocilizumab is administered for the management of cytokine-release syndrome in the RO6958688-containing arms.

DRUG

Ipatasertib

Ipatasertib will be administered orally once a day on Days 1-21 of each 28-day cycle.

DRUG

Bevacizumab

Bevacizumab is administered by IV on Day 1 of each 21-day cycle.

DRUG

Sacituzumab Govitecan

Sacituzumab Govitecan is administered by IV on Day 1 and 8 of each 21-day cycle.

OTHER

Radiation

Radiotherapy up to 21 days

DRUG

Evolocumab

Evolocumab is administered subcutaneously at a dose of 140 mg on Days 1 and 15 of each 28-day cycle.

DRUG

Tiragolumab

Tiragolumab is administered on Day 1 of each 21 day cycle.

DRUG

XL092

XL092 is administered orally once a day on Day 1 to Day 21 of a 21 day cycle.

DRUG

Camonsertib

Camonsertib is administered orally on Days 1-3, Days 8-10 of a 21 day cycle.

Trial Locations (32)

2148

Blacktown Hospital, Blacktown

3002

Peter Mac Callum Cancer Center, East Melbourne

10032

Columbia University Medical Center, New York

11217

Taipei Veterans General Hospital, Taipei

13005

Hopital de la Timone, Marseille

19713

Christiana Care Health Services, Newark

21000

Centre Georges Francois Leclerc, Dijon

28040

Fundación Jimenez Díaz, Madrid

28050

Hospital Universitario HM Sanchinarro-CIOCC, Madrid

29010

Hospital Regional Universitario de Malaga, Málaga

31008

Clínica Universidad de Navarra, Pamplona

31100

Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse

33075

CHU de Bordeaux - Groupe Hospitalier Saint-André - Hopital Saint-Andre, Bordeaux

34298

Institut Régional du Cancer de Montpellier, Montpellier

37203

SCRI Oncology Partners, Nashville

44106

University Hospitals Case Medical Center, Cleveland

44115

Institut De Cancerologie De L'Ouest, Saint-Herblain

46010

Hospital Clinico Universitario de Valencia, Valencia

69008

Centre Léon Bérard, Lyon

89169

Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley, Las Vegas

280146

Hospital Universitario La Paz, Madrid

3109601

Rambam Medical Center, Haifa

4941492

Rabin Medical Center, Petah Tikva

52620-00

Chaim Sheba Medical Center, Ramat Gan

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

08308

Korea University Guro Hospital, Seoul

05505

University of Ulsan College of Medicine - Asan Medical Center (AMC) - Asan Cancer Center (ACC), Songpa-gu

08035

Hospital Universitari Vall d'Hebron, Barcelona

E1 2AT

Barts Cancer Institute, London

NE1 4LP

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

SM2 5PT

Royal Marsden Hospital, Sutton

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03337698 - A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer) | Biotech Hunter | Biotech Hunter