The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

PHASE2CompletedINTERVENTIONAL
Enrollment

216

Participants

Timeline

Start Date

May 2, 2018

Primary Completion Date

July 16, 2019

Study Completion Date

October 6, 2019

Conditions
Shock, SepticCritically IllVasoplegic SyndromeSepsis
Interventions
DRUG

Vitamin C

Ascorbic acid 1.5g every 6 hours i.v. while in ICU, until shock resolution for a maximum of ten days

DRUG

Thiamine

Thiamine 200mg every 12 hours i.v. while in ICU, until shock resolution for a maximum of ten days

DRUG

Hydrocortisone,

Hydrocortisone 50mg every 6 hours i.v while in ICU, until shock resolution or for a maximum of 7 days, then tapered or stopped.

Trial Locations (8)

3004

Alfred Hospital, Melbourne

3021

Western Health (Footscray & Sunshine Hospital), Melbourne

3050

Royal Melbourne Hospital, Melbourne

3084

Austin Health, Heidelberg

3468

Monash Health (Monash Medical Centre and Dandenong Hospital), Clayton

Unknown

Geelong University Hospital, Geelong

Wellington Hospital, Wellington

01246-000

Cancer Institute of the State of São Paulo, São Paulo

All Listed Sponsors
collaborator

Austin Hospital, Melbourne Australia

OTHER

collaborator

Melbourne Health

OTHER

collaborator

Barwon Health

OTHER_GOV

collaborator

Monash Health

OTHER

collaborator

The Alfred

OTHER

collaborator

Wellington Hospital

OTHER_GOV

collaborator

Western Health, Australia

OTHER_GOV

lead

Australian and New Zealand Intensive Care Research Centre

OTHER

NCT03333278 - The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial | Biotech Hunter | Biotech Hunter