320
Participants
Start Date
November 27, 2017
Primary Completion Date
November 26, 2027
Study Completion Date
November 26, 2027
JCAR017 (lisocabtagene maraleucel)
Participants will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) for the production of JCAR017. During JCAR017 production, participants may receive bridging anticancer therapy for disease control. Treatment will include lymphodepleting chemotherapy followed by one dose of JCAR017 administered by intravenous (IV) injection.
JCAR017 (lisocabtagene maraleucel) + ibrutinib
Participants eligible for this cohort should be receiving ibrutinib at the time of screening. For participants who previously discontinued ibrutinib, ibrutinib will be started as soon as possible after eligibility is confirmed. Ibrutinib treatment will continue for up to 90 days after JCAR017 infusion (or longer for participants who are receiving benefit from ibrutinib). Participants will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) for the production of JCAR017. During JCAR017 production, participants may receive bridging chemotherapy for disease control. Upon successful generation of JCAR017 product, participants will receive treatment with JCAR017 therapy. Each cycle will include lymphodepleting chemotherapy followed by one dose of JCAR017 administered by intravenous (IV) injection.
JCAR017 (lisocabtagene maraleucel) + venetoclax
Participants will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) for the production of JCAR017. During JCAR017 production, participants will receive venetoclax as bridging anticancer therapy on a weekly ramp up dosing schedule until stopping one day prior to lymphodepletion. Treatment will include lymphodepleting chemotherapy followed by one dose of JCAR017 administered by intravenous (IV) injection, and the day after infusion venetoclax will be re-initiated.
ACTIVE_NOT_RECRUITING
Local Institution - 0035, New York
WITHDRAWN
Columbia University Medical Center, New York
COMPLETED
Local Institution - 0026, New York
RECRUITING
Weill Cornell Medical College, New York
ACTIVE_NOT_RECRUITING
Local Institution - 0029, Pittsburgh
RECRUITING
UPMC Hillman Cancer Center, Pittsburgh
RECRUITING
University of Pennsylvania - Perelman Center for Advanced Medicine, Philadelphia
RECRUITING
University of Pennsylvania Perelman Center for Advanced Medicine, Philadelphia
RECRUITING
Thomas Jefferson University - Clinical Research Institute, Philadelphia
RECRUITING
Thomas Jefferson University, Philadelphia
WITHDRAWN
Local Institution - 0110, Newark
RECRUITING
Georgetown University Medical Center, Washington D.C.
COMPLETED
Local Institution - 0085, Washington D.C.
WITHDRAWN
Local Institution - 0113, Charlottesville
COMPLETED
Local Institution - 0087, Richmond
WITHDRAWN
Virginia Commonwealth University, Richmond
RECRUITING
Duke University Medical Center, Durham
RECRUITING
Duke University Medical Center, Durham
NOT_YET_RECRUITING
Local Institution - 0104, Atlanta
ACTIVE_NOT_RECRUITING
Local Institution - 0019, Atlanta
RECRUITING
The Blood and Marrow Transplant Group of Georgia (BMTGA), Atlanta
RECRUITING
Mayo Clinic - Jacksonville, Jacksonville
RECRUITING
Mayo Clinic, Jacksonville
RECRUITING
University of Alabama at Birmingham, Birmingham
RECRUITING
University of Alabama Birmingham, Birmingham
RECRUITING
Norton Healthcare - Norton Cancer Institute, Louisville
RECRUITING
The Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
University Hospitals Cleveland Medical Center, Cleveland
RECRUITING
Franciscan St. Francis Health - Indiana Blood and Marrow Transplantation (IBMT), Indianapolis
RECRUITING
University Of Michigan Comprehensive Cancer Center, Ann Arbor
RECRUITING
Barbara Ann Karmanos Cancer Institute, Detroit
ACTIVE_NOT_RECRUITING
Local Institution - 0062, Detroit
NOT_YET_RECRUITING
Local Institution - 0109, Detroit
RECRUITING
Froedtert Hospital BMT Medical College of Wisconsin, Milwaukee
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
Mayo Clinic, Rochester
RECRUITING
Mayo Clinic, Rochester
RECRUITING
Northwestern Memorial Hospital, Chicago
RECRUITING
Northwestern University, Chicago
RECRUITING
University of Chicago Medical Center, Chicago
RECRUITING
University Of Chicago Medical Center, Chicago
NOT_YET_RECRUITING
Local Institution - 0107, Wichita
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
University Of Nebraska Medical Center, Omaha
COMPLETED
Local Institution - 0027, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center (Stephenson Cancer Center), Oklahoma City
RECRUITING
University of Oklahoma Peggy and Charles Stephenson Cancer Center, Oklahoma City
RECRUITING
Baylor University Medical Center, Dallas
COMPLETED
Local Institution - 0083, Dallas
RECRUITING
University of Texas Southwestern Medical Center, Dallas
COMPLETED
Local Institution - 0079, Dallas
RECRUITING
The University of Texas - MD Anderson Cancer Center, Houston
RECRUITING
The University of Texas MD Anderson Cancer Center, Houston
RECRUITING
Colorado Blood Cancer Institute, Denver
RECRUITING
Huntsman Cancer Institute, Salt Lake City
ACTIVE_NOT_RECRUITING
Local Institution - 0028, Salt Lake City
RECRUITING
Banner MD Anderson Cancer Center, Gilbert
RECRUITING
Banner MD Anderson Cancer Center, Gilbert
ACTIVE_NOT_RECRUITING
Local Institution - 0059, Los Angeles
RECRUITING
University of California, Los Angeles, Los Angeles
RECRUITING
City of Hope, Duarte
RECRUITING
City Of Hope, Duarte
RECRUITING
UC San Diego Moores Cancer Center, La Jolla
RECRUITING
University Of California San Diego Moores Cancer Center, La Jolla
ACTIVE_NOT_RECRUITING
Local Institution - 0010, San Francisco
RECRUITING
University of California, San Francisco, San Francisco
COMPLETED
Local Institution - 0098, Eugene
RECRUITING
Fred Hutchinson Cancer Research Center, Seattle
ACTIVE_NOT_RECRUITING
Local Institution - 0018, Seattle
ACTIVE_NOT_RECRUITING
Local Institution - 0005, Boston
RECRUITING
Massachusetts General Hospital, Boston
RECRUITING
Beth Israel Deaconess Medical Center, Boston
ACTIVE_NOT_RECRUITING
Local Institution - 0015, Boston
RECRUITING
University of Michigan Comprehensive Cancer Center, Ann Arbor
NOT_YET_RECRUITING
Local Institution - 0001, Basking Ridge
RECRUITING
Astera Cancer Care, Edison
RECRUITING
John Theurer Cancer Center, Hackensack
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Atlantic Health System / Morristown Medical Center, Morristown
COMPLETED
Local Institution - 0077, New Brunswick
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
Stony Brook University, Stony Brook
RECRUITING
University Hospitals Seidman Cancer Center (Case Western), Cleveland
WITHDRAWN
Local Institution - 0112, Toronto
RECRUITING
Princess Margaret Cancer Centre, Toronto
Juno Therapeutics, a Subsidiary of Celgene
INDUSTRY