To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

273

Participants

Timeline

Start Date

March 7, 2018

Primary Completion Date

November 13, 2020

Study Completion Date

December 10, 2025

Conditions
Metastatic Triple Negative Breast Cancer
Interventions
DRUG

Olaparib Continuous (28-Day cycle) 300 mg BD.

Two (2) 150 mg olaparib tablets should be taken at the same time each day, approximately 12 hours apart with one glass of water (approximately 250 mL).

DRUG

Ceralasertib 160 mg OD + olaparib continuous 300 mg BD (28-day cycle).

Patients will be administered Ceralasertib OD at 160 mg from Day 1 to Day 7 (inclusive) of every 28-day cycle.

DRUG

Adavosertib 150 mg BD + olaparib 200 mg BD (21-day cycle).

Patients will be administered adavosertib BD at 150mg from Day 1 to Day 3 and Day 8 to Day 10.

Trial Locations (141)

333

Research Site, Taoyuan District

500

Research Site, Changhua

1000

Research Site, Brussels

1200

Research Site, Brussels

1307

Research Site, Dresden

1340

Research Site, Ottignies

2610

Research Site, Wilrijk

2930

Research Site, Brasschaat

3000

Research Site, Leuven

4000

Research Site, Liège

5000

Research Site, Namur

6000

Research Site, Charleroi

10003

Research Site, Cáceres

10048

Research Site, Taipei

10123

Research Site, Torino

10449

Research Site, Taipei

10549

Research Site, Mount Kisco

11042

Research Site, Lake Success

11217

Research Site, Taipei

11490

Research Site, Taipei

11501

Research Site, Mineola

11733

Research Site, East Setauket

11794

Research Site, Stony Brook

13273

Research Site, Marseille

13620

Research Site, Seongnam-si

14076

Research Site, Caen

16128

Research Site, Genova

20014

Research Site, San Sebastián

20089

Research Site, Rozzano

20133

Research Site, Milan

20141

Research Site, Milan

20357

Research Site, Hamburg

21204

Research Site, Towson

23900

Research Site, Lecco

25030

Research Site, Besançon

25124

Research Site, Brescia

27100

Research Site, Pavia

28007

Research Site, Madrid

28034

Research Site, Madrid

28040

Research Site, Madrid

28046

Research Site, Madrid

28100

Research Site, Novara

28644

Research Site, Cheongju-si

30559

Research Site, Hanover

33076

Research Site, Bordeaux

34298

Research Site, Montpellier

35000

Research Site, Rennes

35205

Research Site, Birmingham

36312

Research Site, Vigo

37044

Research Site, Tours

37909

Research Site, Knoxville

40138

Research Site, Bologna

40207

Research Site, Louisville

40447

Research Site, Taichung

41009

Research Site, Seville

41013

Research Site, Seville

41404

Research Site, Daegu

41701

Research Site, Hazard

43126

Research Site, Parma

44124

Research Site, Cona

44202

Research Site, Nantes

44805

Research Site, Saint-Herblain

45219

Research Site, Cincinnati

46010

Research Site, Valencia

46321

Research Site, Munster

47014

Research Site, Meldola

49055

Research Site, Angers

50009

Research Site, Zaragoza

53100

Research Site, Siena

53212

Research Site, Milwaukee

56126

Research Site, Pisa

58452

Research Site, Witten

59000

Research Site, Lille

60126

Research Site, Ancona

60431

Research Site, Frankfurt am Main

60637

Research Site, Chicago

62100

Research Site, Macerata

69373

Research Site, Lyon

80045

Research Site, Aurora

80131

Research Site, Napoli

81675

Research Site, München

83342

Research Site, Kaohsiung Hsien

85234

Research Site, Gilbert

94805

Research Site, Villejuif

98104

Research Site, Seattle

98125

Research Site, Messina

99508

Research Site, Anchorage

06511

Research Site, New Haven

08724

Research Site, Brick

T2N 4N2

Research Site, Calgary

V1Y 5L3

Research Site, Kelowna

K1H 8L6

Research Site, Ottawa

M4N 3M5

Research Site, Toronto

625 00

Research Site, Brno

775 20

Research Site, Olomouc

180 81

Research Site, Prague

04103

Research Site, Leipzig

T12 DV56

Research Site, Cork

Unknown

Research Site, Dublin

00128

Research Site, Roma

4819 EV

Research Site, Breda

3015 GD

Research Site, Rotterdam

2545 CH

Research Site, The Hague

41-300

Research Site, Dąbrowa Górnicza

80-952

Research Site, Gdansk

81-519

Research Site, Gdynia

72-003

Research Site, Grzepnica

31-531

Research Site, Krakow

91-211

Research Site, Lodz

10-228

Research Site, Olsztyn

60-192

Research Site, Poznan

02-781

Research Site, Warsaw

53-413

Research Site, Wroclaw

1400-038

Research Site, Lisbon

1769-001

Research Site, Lisbon

2674-514

Research Site, Loures

4099-001

Research Site, Porto

4434-502

Research Site, Vila Nova de Gaia

410-769

Research Site, Goyang-si

405-760

Research Site, Incheon

02841

Research Site, Seoul

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

08035

Research Site, Barcelona

08036

Research Site, Barcelona

07120

Research Site, Palma de Mallorca

08190

Research Site, Sant Cugat del Vallès

AB25 2ZN

Research Site, Aberdeen

BS1 2NT

Research Site, Bristol

CF14 2TL

Research Site, Cardiff

DH1 5TW

Research Site, Durham

EH4 2XR

Research Site, Edinburgh

LE1 5WW

Research Site, Leicester

SE1 9RT

Research Site, London

W1G 6AD

Research Site, London

W1T 7HA

Research Site, London

M20 4BX

Research Site, Manchester

NG5 1PB

Research Site, Nottingham

SO16 6YD

Research Site, Southampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY