Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

223

Participants

Timeline

Start Date

October 19, 2017

Primary Completion Date

February 22, 2022

Study Completion Date

January 4, 2023

Conditions
Avelumab in Combination With Talazoparib Will be Investigated in Patients With Locally Advanced (Primary or Recurrent) or Metastatic Solid Tumors
Interventions
DRUG

Avelumab Phase 1b

Avelumab

DRUG

Talazoparib Phase 1b

Talazoparib

DRUG

Avelumab Phase 2

The dose will be determined after the overall available data (including safety and preliminary anti tumor activity) emerging from the Phase 1b portion of the study have been evaluated.

DRUG

Talazoparib Phase 2

The dose will be determined after the overall available data (including safety and preliminary anti tumor activity) emerging from the Phase 1b portion of the study have been evaluated.

Trial Locations (66)

1000

Institut Jules Bordet, Brussels

1200

Cliniques Universitaires Saint-Luc, Brussels

2065

Northern Cancer Institute, St Leonards

Northern Cancer Institute, Sydney

2100

Phase 1 Unit, Department of Oncology, Section 5073., Copenhagen

2109

Macquarie University, North Ryde

2730

Herlev og Gentofte Hospital, Herlev

The Experimental Cancer Therapy Unit, Herlev

3529

CRU Hungary Kft., Miskolc

4101

Mater Misericordiae Ltd, Brisbane

6000

Grand Hôpital de Charleroi - Site Notre-Dame, Charleroi

6150

Fiona Stanley Hospital, Murdoch

10016

NYU Investigational Pharmacy, New York

NYU Langone Medical Center, New York

NYU Langone Radiology, New York

NYU Laura and Isaac Perlmutter Cancer Center, New York

10017

NYU Langone Radiology - Ambulatory Care Center, New York

10029

Icahn School of Medicine at Mount Sinai, New York

Mount Sinai Hospital- Pharmacy department, New York

14263

Roswell Park Cancer Center Institute, Buffalo

20007

Georgetown University Medical Center, Washington D.C.

21565

Gachon University Gil Medical Center, Incheon

44106

Cleveland Clinic Taussig Cancer Center Investigational Pharmacy, Cleveland

44195

Cleveland Clinic, Cleveland

55455

University Of Minesota Health: Clinics And Surgery Center, Minneapolis

University of Minesota Medical Center, Fairview IDS Pharmacy, Minneapolis

University of Minnesota Medical Center, Fairview, Minneapolis

72703

Highlands Oncology Group, Fayetteville

Highlands Oncology, Fayetteville

72758

Highlands Oncology Group, Rogers

Highlands Oncology, Rogers

72762

Highlands Oncology Group, Springdale

Highlands Oncology, Springdale

77030

The University of Texas MD Anderson Cancer Center, Houston

90033

Keck Hospital of USC, Los Angeles

LAC+USC Medical Center, Los Angeles

USC/Norris Comprehensive Cancer Center/Investigational Drug Services, Los Angeles

USC/Norris Comprehensive Cancer Center, Los Angeles

90048

Cedars-Sinai Medical Center, Los Angeles

90211

Tower Hematology Oncology Medical Group, Beverly Hills

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

94304

Freidenrich Center for Translational Research (CTRU), Palo Alto

94305

Stanford Cancer Institute, Stanford

Stanford Hospital and Clinics, Stanford

Stanford Women's Cancer Center, Stanford

115478

"FSBI National Medical Research Centre of Oncology n.a.", Moscow

150054

"State budgetary institution of healthcare of Yaroslavl region Clinical oncology hospital", Yaroslavl

249036

Medical Radiological Research Center n.a. A.F. Tsyba -, Obninsk

Medical Radiological Research Center n.a. A.F. Tsyba, Obninsk

454087

GBUZ, Chelyabinsk

644013

"Budget Healthcare Institution of Omsk Region Clinical Oncology Dispensary", Omsk

02114

Massachusetts General Hospital (MGH), Boston

Massachusetts General Hospital Attn: Lalit Joshi, Boston

Massachusetts General Hospital Attn: Svetlana Rashkova, Boston

02115

Brigham & Women's Hospital, Boston

02215

Dana Farber Cancer Institute, Attn: Vasilika Koci, PharmD, Boston

Dana-Farber Cancer Institute, Boston

T6G 1Z2

Cross Cancer Institute, Edmonton

M5G 2M9

Princess Margaret Cancer Centre, Toronto

H-1122

Orszagos Onkologiai Intezet, Budapest

H-7624

Pecsi Tudomanyegyetem, Pécs

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

W1T 7HA

University College London Hospitals NHS Foundation Trust, London

LE1 5WW

University Hospitals of Leicester NHS Trust, Leicester

NE7 7DN

Freeman Hospital, The Sir Bobby Robson Cancer Trials, Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT03330405 - Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors | Biotech Hunter | Biotech Hunter