Immunogenicity of Alternative Annual Influenza Vaccination Strategies in Older Adults in Hong Kong

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

1,861

Participants

Timeline

Start Date

October 7, 2017

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Influenza, Human
Interventions
BIOLOGICAL

Standard inactivated influenza vaccine (NH formulation)

0.5mL FluQuadri®, Sanofi Pasteur, containing 60μg antigen - 15μg for each influenza strain included - with strains recommended by the WHO for the northern hemisphere formulation.

BIOLOGICAL

MF 59 adjuvanted inactivated influenza vaccine (NH formulation)

0.5mL FLUAD(TM), Seqirus containing 45μg antigen; 15μg for each influenza strain included and MF59C.1 adjuvant (MF59®) with strains recommended by the WHO for the northern hemisphere formulation.

BIOLOGICAL

High-dose inactivated influenza vaccine (NH formulation)

0.5mL Fluzone® High-Dose, Sanofi Pasteur containing 180μg antigen; 60μg for each influenza strain included with strains recommended by the WHO for the northern hemisphere formulation.

BIOLOGICAL

Recombinant hemagglutinin inactivated influenza vaccine (NH formulation)

0.5mL Flublok®, Protein Sciences Corporation containing 180μg antigen, 45μg for each influenza strain included with strains recommended by the WHO for the northern hemisphere formulation.

Trial Locations (1)

Unknown

The University of Hong Kong, Hong Kong

All Listed Sponsors
collaborator

Centers for Disease Control and Prevention

FED

lead

The University of Hong Kong

OTHER