DS-8201a in Human Epidermal Growth Factor Receptor 2 (HER2)-Expressing Gastric Cancer [DESTINY-Gastric01]

PHASE2CompletedINTERVENTIONAL
Enrollment

233

Participants

Timeline

Start Date

November 2, 2017

Primary Completion Date

November 8, 2019

Study Completion Date

December 11, 2020

Conditions
Neoplasm, Gastrointestinal
Interventions
DRUG

DS-8201a

DS-8201a is comprised of an antibody component conjoined to a drug component in a lyophilized powder, which is made into solution for intravenous administration.

DRUG

Physician's Choice

"Either:~Irinotecan monotherapy (Starting dosage and usage is 150 mg/m2 biweekly, with dose reduction permitted)~Paclitaxel monotherapy (Starting dosage and usage is 80 mg/m2 weekly, with dose reduction permitted)"

Trial Locations (66)

10408

National Cancer Center, Ilsan

13620

Seoul National University Bundang Hospital, Seongnam

21565

Gachon University Gil Medical Center, Incheon

28644

Chungbuk National University Hospital, Cheongju-si

41404

Kyungpook National University Chilgok Hospital, Daegu

48108

Inje University Haeundae Paik Hospital, Busan

49201

Dong-A University Hospital, Busan

54907

Chonbuk National University Hospital, Jeonju

58128

Chonnam National University Hwasun Hospital, Gwangju

464-8681

Aichi Cancer Center Hospital, Nagoya

036-8563

Hirosaki University Hospital, Hirosaki

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

806-8501

Japan Community Health Care Organization Kyushu Hospital, Kitakyushu

373-8550

Gunma Prefectural Cancer Center, Ōta

737-0023

Kure Medical Center, Kure

060-8648

Hokkaido University Hospital, Sapporo

673-8558

Hyogo Cancer Center, Akashi

660-8511

Kansai Rosai Hospital, Amagasaki

650-0047

Kobe City Medical Center General Hospital, Kobe

309-1793

Ibaraki Prefectural Central Hospital, Kasama

920-8641

Kanazawa University Hospital, Kanazawa

028-3695

Iwate Medical University Hospital, Shiwa-gun

761-0793

Kagawa University Hospital, Kita

216-8511

St. Marianna University School of Medicine Hospital, Kawasaki

252-0375

The Kitasato Institute Kitasato University Hospital, Sagamihara

232-0024

Yokohama City University Medical Center, Yokohama

241-8515

Kanagawa Cancer Center, Yokohama

602-8026

Japanese Red Cross Kyoto Daini Hospital, Kamigyō-ku

981-1293

Miyagi Cancer Center, Natori-shi

989-6183

Osaki Citizen Hospital, Ōsaki

565-0871

Osaka University Hospital, Suita

560-8565

Toyonaka Municipal Hospital, Toyonaka

320-0834

Tochigi Cancer Center, Utsunomiya

113-8677

Tokyo Metropolitan Komagome Hospital, Bunkyō-Ku

104-0045

National Cancer Center Hospital, Chuo Ku

135-8550

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-Ku

135-8577

Showa University Koto Toyosu Hospital, Koto-Ku

105-8470

Toranomon Hospital, Minato-Ku

260-8717

Chiba Cancer Center, Chiba

910-8526

Fukui Prefectural Hospital, Fukui

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

812-8582

Kyushu University Hospital, Fukuoka

501-1194

Gifu University Hospital, Gifu

731-0293

Hiroshima City Asa Citizens Hospital, Hiroshima

734-8530

Hiroshima Prefectural Hospital, Hiroshima

781-8555

Kochi Health Sciences Center, Kochi

951-8566

Niigata Cancer Center Hospital, Niigata

700-8558

Okayama University Hospital, Okayama

534-0021

Local Incorporated Administrative Agency Osaka City Hospital Organization Osaka City General Hospital, Osaka

541-8567

Osaka International Cancer Institute, Osaka

558-8558

Osaka General Medical Center, Osaka

589-8511

Kindai University Hospital, Osaka

362-0806

Saitama Cancer Center, Saitama

411-8777

Shizuoka Cancer Center, Shizuoka

420-8527

Shizuoka General Hospital, Shizuoka

160-8582

Keio University Hospital, Tokyo

02841

Korea University Anam Hospital, Seoul

03080

Seoul National University Hospital, Seoul

03722

Yonsei Cancer Center, Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06273

Gangnam Severance Hospital, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

06973

Chung-Ang University Hospital, Seoul

08308

Korea University Guro Hospital, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Daiichi Sankyo Co., Ltd.

INDUSTRY