292
Participants
Start Date
March 1, 2018
Primary Completion Date
May 29, 2020
Study Completion Date
July 7, 2021
Belimumab
Belimumab will be administered as SC injection once weekly via autoinjector in thigh or abdomen
Rituximab
Rituximab will be administered as IV infusion of 1000mg at Week 4 and Week 6
Rituximab-placebo
Saline will be administered as IV infusions at Week 4 and Week 6
Standard therapy (Including Immunosuppressants)
Standard therapy will contain stable SLE medications including immunosuppressant to be administered from baseline through Week 104.
Standard therapy (Excluding Immunosuppressants)
Standard therapy excluding Immunosuppressant will contain anti-malarials, NSAIDs, and/or corticosteroids with prednisone dose equivalent to \<= 5 mg/day will administered through Week 104.
Steroid Taper
Steroid taper will include prednisone doses equivalent to =\< 5 mg/day in all Arms through Week 104.
GSK Investigational Site, New York
GSK Investigational Site, New York
GSK Investigational Site, Manhasset
GSK Investigational Site, Pittsburgh
GSK Investigational Site, Kiel
GSK Investigational Site, Charlotte
GSK Investigational Site, Summerville
GSK Investigational Site, Brest
GSK Investigational Site, Hanover
GSK Investigational Site, Miami
GSK Investigational Site, Aventura
GSK Investigational Site, Tamarac
GSK Investigational Site, Pessac
GSK Investigational Site, Tampa
GSK Investigational Site, Tampa
GSK Investigational Site, Birmingham
GSK Investigational Site, Vigo (Pontevedra)
GSK Investigational Site, Zapopan
GSK Investigational Site, Vandalia
GSK Investigational Site, Valencia
GSK Investigational Site, Valladolid
GSK Investigational Site, Brighton
GSK Investigational Site, Lansing
GSK Investigational Site, Lansing
GSK Investigational Site, Glendale
GSK Investigational Site, Lille
GSK Investigational Site, Frankfurt
GSK Investigational Site, Strasbourg
GSK Investigational Site, Oklahoma City
GSK Investigational Site, Paris
GSK Investigational Site, Paris
GSK Investigational Site, League City
GSK Investigational Site, Austin
GSK Investigational Site, Denver
GSK Investigational Site, Las Cruces
GSK Investigational Site, Upland
GSK Investigational Site, La Mesa
GSK Investigational Site, San Leandro
GSK Investigational Site, Mérida
GSK Investigational Site, Spokane
GSK Investigational Site, Moscow
GSK Investigational Site, Yaroslavl
GSK Investigational Site, Petrozavodsk
GSK Investigational Site, Saint Petersburg
GSK Investigational Site, Ryazan
GSK Investigational Site, Kazan'
GSK Investigational Site, Ulyanovsk
GSK Investigational Site, Ufa
GSK Investigational Site, Chelyabinsk
GSK Investigational Site, Novosibirsk
GSK Investigational Site, Omsk
GSK Investigational Site, Kemerovo
GSK Investigational Site, Orlando
GSK Investigational Site, Ann Arbor
GSK Investigational Site, Ciudad Autonoma de Buenos Aires
GSK Investigational Site, La Plata
GSK Investigational Site, San Miguel de Tucumán
GSK Investigational Site, Salvador
GSK Investigational Site, Cuiabá
GSK Investigational Site, Juiz de Fora
GSK Investigational Site, São José do Rio Preto
GSK Investigational Site, Hamilton
GSK Investigational Site, Toronto
GSK Investigational Site, Trois-Rivières
GSK Investigational Site, Saskatoon
GSK Investigational Site, Amersfoort
GSK Investigational Site, Groningen
GSK Investigational Site, Leiden
GSK Investigational Site, The Hague
GSK Investigational Site, Utrecht
GSK Investigational Site, Daegu
GSK Investigational Site, Gwangju
GSK Investigational Site, Incheon
GSK Investigational Site, Seoul
GSK Investigational Site, Seoul
GSK Investigational Site, Seoul
GSK Investigational Site, Suwon
GSK Investigational Site, Badalona
GSK Investigational Site, Barcelona
Lead Sponsor
GlaxoSmithKline
INDUSTRY