TPF+CCRT vs.CCRT+PF in High Risk Nasopharyngeal Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

322

Participants

Timeline

Start Date

November 13, 2017

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2026

Conditions
Nasopharyngeal Carcinoma
Interventions
DRUG

TPF+CCRT

"Patients receive paclitaxel liposome (135mg/m2 on day 1) , cisplatin (25mg/m2 on day 1-3) and 5-fluorouracil (750mg/m2 civ 120h) every three weeks for three cycles of induction chemotherapy before radiotherapy.~Patients receive IMRT and cisplatin (100mg/m2) every three weeks for three cycles during radiotherapy (D1,D22,D43 of RT)"

DRUG

CCRT+ PF

"Patients receive cisplatin (80mg/m2 on day 1) and 5-fluorouracil (1000mg/m2 civ 96h) every four weeks for three cycles 4 weeks after radiotherapy.~Patients receive IMRT and cisplatin (100mg/m2) every three weeks for three cycles during radiotherapy (D1,D22,D43 of RT)"

Trial Locations (1)

510060

Sun Yat-sen Universitty Cancer Center, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER