Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism

PHASE3UnknownINTERVENTIONAL
Enrollment

135

Participants

Timeline

Start Date

May 11, 2017

Primary Completion Date

March 1, 2018

Study Completion Date

March 1, 2018

Conditions
HyperthyroidismGraves Disease
Interventions
DRUG

Cholestyramine Powder 4g

Cholestyramine powder 4g twice daily, Tablet Carbimazole 30 mg daily, Tablet propanolol 40 mg twice daily for 4 weeks

DRUG

Prednisolone

Tablet prednisolone 30 mg daily for week 1, 20 mg daily for week 2, 10 mg daily for week 3 and 5 mg daily for week 4, Tablet carbimazole 30 mg daily, Tablet propanolol 40 mg twice daily for 4 weeks

DRUG

Standard treatment

Carbimazole 30 mg daily and propanolol 40 mg twice daily for 4 weeks

Trial Locations (3)

62250

RECRUITING

Hospital Putrajaya, Putrajaya

68000

RECRUITING

Hospital Ampang, Ampang

88300

RECRUITING

Hospital Queen Elizabeth 2, Kota Kinabalu

All Listed Sponsors
lead

Clinical Research Centre, Malaysia

OTHER

collaborator

Ministry of Health, Malaysia

OTHER_GOV