BLASST-1 (Bladder Cancer Signal Seeking Trial): Nivolumab, Gemcitabine, and Cisplatin in Treatment of Muscle Invasive Bladder Cancer (MIBC) Undergoing Cystectomy

PHASE2CompletedINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

January 29, 2018

Primary Completion Date

June 5, 2020

Study Completion Date

July 1, 2021

Conditions
Muscle Invasive Bladder Cancer
Interventions
DRUG

Nivolumab

Nivolumab will be given at a fixed dose of 360 mg IV over 30 minutes on Day 8 every 21 days for 4 cycles.

DRUG

Cisplatin

Cisplatin will be given at 70 mg/m2 IV over 30 minutes on Day 1 every 21 days, and based on treating physician's discretion, split-dose cisplatin can be given at 35 mg/m2 IV Day 1 and Day 8 every 21 days for 4 cycles.

DRUG

Gemcitabine

Gemcitabine will be given at 1000 mg/m2 IV over 30 minutes on days 1, 8, and every 21 days for 4 cycles.

Trial Locations (3)

55455

Masonic Cancer Center - University of Minnesota, Minneapolis

84112

Huntsman Cancer Institute - University of Utah Health, Salt Lake City

02215

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Masonic Cancer Center, University of Minnesota

OTHER

NCT03294304 - BLASST-1 (Bladder Cancer Signal Seeking Trial): Nivolumab, Gemcitabine, and Cisplatin in Treatment of Muscle Invasive Bladder Cancer (MIBC) Undergoing Cystectomy | Biotech Hunter | Biotech Hunter