A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

272

Participants

Timeline

Start Date

December 21, 2017

Primary Completion Date

July 1, 2025

Study Completion Date

July 1, 2025

Conditions
MelanomaNon-Small Cell Lung CancerBladder CancerColorectal CancerTriple Negative Breast CancerRenal CancerHead and Neck CancerOther Solid Cancers
Interventions
DRUG

Autogene cevumeran

Autogene cevumeran will be administered by intravenous (IV) infusion, in 21-day cycles.

DRUG

Atezolizumab

Atezolizumab will be administered by IV infusion on Day 1 of every 21-day cycle.

Trial Locations (26)

4000

CHU de Liège (Sart Tilman), Liège

9000

UZ Gent, Ghent

10032

Columbia University Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

31008

Clinica Universitaria de Navarra, Pamplona

34376

Fachklinik für Lungenerkrankungen, Immenhausen

37203

Sarah Cannon Res Inst, Nashville

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75185

Akademiska sjukhuset, Onkologkliniken, Uppsala

85258

HonorHealth Research Institute ? Bisgrove, Scottsdale

89169

Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley, Las Vegas

94143

UCSF Comprehensive Cancer Ctr, San Francisco

94305

Stanford Cancer Center, Stanford

97213

Providence Oncology and Hematology Care Eastside, Portland

98109

Seattle Cancer Care Alliance, Seattle

80045-2517

University of Colorado, Aurora

06511

Yale University Cancer Center, Smilow Cancer Hospital, New Haven

02114

Massachusetts General Hospital., Boston

02215

Dana Farber Can Ins, Boston

K1H 8L6

The Ottawa Hospital Cancer Centre, Ottawa

M5G 2M9

Princess Margaret Cancer Center, Toronto

1066 CX

Antoni van Leeuwenhoek Ziekenhuis, Amsterdam

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

EC1A 7BE

Barts & London School of Med, London

SO16 6YD

Southampton General Hospital, Southampton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

BioNTech SE

INDUSTRY

lead

Genentech, Inc.

INDUSTRY