Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps

NACompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 28, 2014

Primary Completion Date

February 28, 2017

Study Completion Date

September 19, 2018

Conditions
Optimal Tissue Perfusion
Interventions
OTHER

Fluid management

Primary fluid admission: 1 mL/bodyweight kg/ hour crystalloid. If Pulse pressure variation is lower than 10%; 250 mL/15 min of colloid or crystalloid is administered depending on randomization.

DRUG

Norepinephrine

Norepinephrine is administered if Mean arterial pressure drops below 65 mmHg. Mean arterial pressure must be maintained above 65 mmHg. Norepinephrine is titrated accordingly.

DRUG

Dobutamine

Dobutamine is administered if Cardiac index drops below 2.5 L/min/m2. Cardiac index must be maintained above 2.5 L/min/m2. Dobutamine is titrated accordingly.

Trial Locations (1)

6725

Department of Anaesthesiology and Intensive Therapy, Szeged

All Listed Sponsors
collaborator

Department of Oral and Maxillofacial Surgery, University of Szeged

UNKNOWN

collaborator

Institute of Surgical Research, University of Szeged

UNKNOWN

lead

Szeged University

OTHER

NCT03288051 - Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps | Biotech Hunter | Biotech Hunter