MCS110 Combined With Neoadjuvant Doxorubicin, Cyclophosphamide, and Weekly Paclitaxel in Patients With Hormone-Receptor Positive and HER2- Breast Cancer

PHASE1WithdrawnINTERVENTIONAL
0
Timeline

Start Date

September 30, 2018

Primary Completion Date

October 31, 2019

Study Completion Date

February 28, 2021

Conditions
Breast CancerCancer of Breast
Interventions
BIOLOGICAL

MCS110

-MCS110 is an IgG1/κ humanized monoclonal antibody directed against human macrophage colony stimulating factor

DRUG

Doxorubicin

-Standard of care

DRUG

Cyclophosphamide

-Standard of care

DRUG

Paclitaxel

-Standard of care

PROCEDURE

Bone marrow aspirate

-Time of enrollment and at time of surgery

PROCEDURE

Peripheral blood samples

-Time of enrollment and at time of surgery

PROCEDURE

Tumor tissue

-Time of enrollment and at time of surgery

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

lead

Washington University School of Medicine

OTHER