A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)

PHASE2CompletedINTERVENTIONAL
Enrollment

88

Participants

Timeline

Start Date

December 22, 2017

Primary Completion Date

July 22, 2020

Study Completion Date

July 22, 2020

Conditions
Sickle Cell Disease
Interventions
DRUG

IW-1701

Oral Tablet

DRUG

Placebo

Oral Tablet

Trial Locations (37)

10461

Jacobi Medical Center, The Bronx

10595

New York Medical College, Valhalla

15232

University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh

19046

The Clinical Trial Center LLC, Jenkintown

20010

MedStar Health Research Institute, MedStar Washington Hospital Center, Washington D.C.

20060

Howard University Center for Sickle Cell Disease, Washington D.C.

21201

University of Maryland Medical Center, Baltimore

21205

Johns Hopkins School of Medicine Children's Center, Baltimore

23298

Virginia Commonwealth University - Clinical Research Unit, Richmond

27834

East Carolina University - Leo W. Jenkins Cancer Center, Greenville

East Carolina University Brody School of Medicine, Department of Pediatrics, Division of Pediatric Hematology, Greenville

30303

Grady Memorial Hospital, Atlanta

30331

Atlanta Center for Medical Research, Atlanta

32117

Century Clinical Research, Inc., Fort Lauderdale

32810

Omega Research Maitland, LLC, Orlando

33021

Foundation for Sickle Cell Disease Research, Hollywood

Children's Hospital of Michigan-Detroit, Detroit

33180

Innovative Medical Research of South Florida, Inc., Aventura

53226

Blood Center of Wisconsin (BCW), Wauwatosa

60422

Healthcare Research Network II, LLC, Flossmoor

60612

University of Illinois at Chicago, Chicago

63042

Healthcare Research Network, Hazelwood

70601

Clinical Trials of SWLA, LLC, Lake Charles

74105

Lynn Institute of Tulsa, Tulsa

77030

"UT Health Clinical Research Unit Center for Clinical and Translational Sciences", Houston

77521

Accurate Clinical Research, Baytown

78229

Mays Cancer Center UT Health San Antonio, San Antonio

92868

Children's Hospital of Orange County, Orange

02115

Boston Children's Hospital, Boston

07601

Hackensack University Medical Center, Pediatric Hematology and Oncology, Hackensack

Unknown

Hammoud Hospital University Medical Center, Sidon

Nini Hospital, Tripoli

E1 2ES

Royal London Hospital, London

N19 5NF

Whittington Hospital, London

SE1 7EH

Guys and St Thomas NHS Foundation Trust - Evelina London Childrens Hospital, London

SE1 9RT

Guy's Hospital, London

W12 0NN

Hammersmith Hospital, London

Sponsors
All Listed Sponsors
lead

Cyclerion Therapeutics

INDUSTRY