Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

October 19, 2017

Primary Completion Date

November 9, 2023

Study Completion Date

January 17, 2024

Conditions
Primary Progressive Multiple SclerosisSecondary Progressive Multiple Sclerosis
Interventions
BIOLOGICAL

ATA188

ATA188 is being investigated as an off-the-shelf, allogeneic T-cell immunotherapy for the treatment of EBV+ progressive multiple sclerosis.

DRUG

Placebo

Placebo matching to ATA188

Trial Locations (31)

2170

Liverpool Hospital, Liverpool

4029

Royal Brisbane and Women's Hospital, Brisbane

4222

Griffith University, School of Medicine, Southport

10032

Columbia University Medical Center-The Neurological Institute of New York, New York

14226

Dent Neurologic Institute, Amherst

14642

University of Rochester Medical Center - URMC, Rochester

22182

MS Center of Greater Washington, Vienna

28117

PMG Research of Piedmont Healthcare, Mooresville

29650

Premier Neurology P.C., Greer

32751

Neurology Associates, PA-Maitland, Maitland

33612

University of South Florida, Morsani College of Medicine, Tampa

37064

Advanced Neurosciences Institute ANI - Franklin, Franklin

37215

Vanderbilt Comprehensive Multiple Sclerosis Center, Nashville

46825

Fort Wayne Neurological Center, Fort Wayne

53226

Medical College of Wisconsin, Milwaukee

63110

Washington University in St. Louis, St Louis

66160

University of Kansas Medical Center KUMC - Multiple Sclerosis MS Center, Kansas City

70121

Ochsner Clinic Foundation, New Orleans

77030

The University of Texas Health Science Center at Houston, Houston

80045

University of Colorado, Aurora

80528

Advanced Neurology, Fort Collins

90027

Kaiser Permanente MS Clinic Los Angeles, Los Angeles

92037

University of California, San Diego, La Jolla

94158

University of California San Francisco, San Francisco

94304

Stanford University, Palo Alto

99202

Inland Northwest Research LLC, Spokane

02481

Dragonfly Research, Wellesley

19104-5127

University of Pennsylvania, Philadelphia

V5G 2X6

Fraser Health Multiple Sclerosis Clinic, Burnaby

M5B1W8

Unity Health Toronto/St. Michael's Hospital, Toronto

J4V2J2

Recherche Sepmus Inc., Greenfield Park

Sponsors
All Listed Sponsors
lead

Atara Biotherapeutics

INDUSTRY

NCT03283826 - Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis | Biotech Hunter | Biotech Hunter