Immunotherapy and SBRT for Metastatic Head and Neck Carcinomas

SBRT to 2-5 oligometastases will be administered between Cycle 2 and 3 of durvalumab and tremelimumab. All SBRT will be completed within a 3-week period.

Durvalumab (1500 mg IV q4weeks) for 4 cycles in combination with tremelimumab. Then, durvalumab alone until confirmed disease progression, death, unacceptable toxicity, withdrawal of consent, or other discontinuation criteria met.

Tremelimumab (75mg IV q4weeks) for 4 cycles in combination with Durvalumab.