Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma

PHASE2UnknownINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

December 12, 2017

Primary Completion Date

June 4, 2023

Study Completion Date

June 4, 2023

Conditions
Renal Cell Carcinoma, Clear CellMetastatic Kidney Cancer
Interventions
DRUG

Pembrolizumab plus denosumab

Pembrolizumab 200 mg IV every 3 weeks plus denosumab 120 mg SC on day 1, 8, 22 and then every 3 weeks with daily oral calcium and vitamin D

Trial Locations (16)

2010

St Vincent's Hospital Sydney, Sydney

2086

Northern Cancer Institute, Frenchs Forest

2229

St George, Sydney

2298

Calvary Mater Newcastle, Newcastle

2640

Border Medical Oncology Research Unit, Albury

3128

Box Hill, Box Hill

4029

Royal Brisbane and Womens hospital, Herston

4575

Sunshine Coast University Hospital, Birtinya

4814

Townsville Hospital, Townsville

6150

Fiona Stanley Hospital, Perth

Unknown

Concord Repatriation General Hospital, Sydney

Icon Cancer Care, Brisbane

Flinders Medical Centre, Adelaide

Monash Health, Melbourne

Peter MacCallum Cancer Center, Melbourne

Ballarat Oncology & Haematology Services, Wendouree

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Amgen

INDUSTRY

lead

Australian and New Zealand Urogenital and Prostate Cancer Trials Group

OTHER

NCT03280667 - Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma | Biotech Hunter | Biotech Hunter