Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis

RecruitingOBSERVATIONAL
Enrollment

1,200

Participants

Timeline

Start Date

July 13, 2017

Primary Completion Date

October 31, 2027

Study Completion Date

October 31, 2027

Conditions
Stroke, AcuteBiological Specimen BanksBiomarkersEtiologyPrognosis
Interventions
OTHER

Collection of thrombus that is responsible for stroke and blood sample

"A blood sample (venous or arterial) of 10 ml will be made, on ethylene Diamine Tetra-Acetic (EDTA) tube (5 ml) and citrate (5 ml).Thrombus resulting from thrombectomy will be collected at the end of the procedure. The samples will be transferred to a biobank. Treatment efficacy, etiology and prognosis of patients will be assessed using the following criteria :~A) TOAST score (etiology) B) TICI score (status of final recanalization) C) Extravasation of contrast agent on post-intervention CT (rupture of the blood-brain barrier :yes/no) D) Symptomatic haemorrhagic transformation corresponding to an increase \> 4 of the NIHSS score due to a haemorrhagic transformation identified on brain imaging 24 hours after stroke E) Decreased NIHSS score by 8 points or NIHSS score = 0 24 hours after stroke (improved neurological status: yes/no) F) Modified RANKIN score (mRS) measured at 3 months evaluating neurological prognosis"

Trial Locations (9)

33000

RECRUITING

CHU de Bordeaux, Bordeaux

35000

RECRUITING

CHU de Rennes, Rennes

54000

RECRUITING

CHRU de Nancy, Nancy

75019

RECRUITING

Fondation Ophtalmologique A. de Rothschild, Paris

83000

NOT_YET_RECRUITING

Hôpital d'Instruction des Armées Sainte-Anne, Toulon

87000

NOT_YET_RECRUITING

Chu Limoges, Limoges

Unknown

RECRUITING

CHU Caen, Caen

44 093

RECRUITING

CHU de Nantes, Nantes

92 150

RECRUITING

Hôpital Foch,, Suresnes

All Listed Sponsors
lead

Fondation Ophtalmologique Adolphe de Rothschild

NETWORK