Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma

PHASE1TerminatedINTERVENTIONAL
Enrollment

85

Participants

Timeline

Start Date

October 2, 2017

Primary Completion Date

November 11, 2019

Study Completion Date

November 11, 2019

Conditions
Cholangiocarcinoma Non-resectableCholangiocarcinoma, IntrahepaticCholangiocarcinoma, ExtrahepaticGallbladder Adenocarcinoma
Interventions
DRUG

PEGPH20

PEGPH20 will be administered as per the schedule specified in the respective arms.

DRUG

CIS

CIS will be administered as per the schedule specified in the respective arms.

DRUG

GEM

GEM will be administered as per the schedule specified in the respective arms.

DRUG

Atezolizumab

Atezolizumab will be administered as per the schedule specified in the respective arms.

Trial Locations (36)

10029

Mount Sinai, New York

10330

King Chulalongkorn Memorial Hospital, Bangkok

13620

Seoul National University Bundang Hospital, Seongnam-si

14642

University of Rochester Medical Center, Rochester

15232

University of Pittsburgh Cancer Institute, Pittsburgh

20007

Lombardi Cancer Center, Georgetown University, Washington D.C.

21287

Johns Hopkins, Baltimore

27710

Duke Cancer Institute, Durham

29425

Medical University of South Carolina, Charleston

44718

Gabrail Cancer Center, Canton

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

53226

Froedtert Hospital And Medical College, Milwaukee

63110

Washington University School of Medicine, St Louis

77030

MD Anderson Cancer Center, Houston

78229

UT Health Cancer Center, San Antonio

84112

Huntsman Cancer Institute, Salt Lake City

85054

Mayo Clinic of Arizona, Phoenix

85724

University of Arizona, Tucson

90033

USC/Norris Comprehensive Cancer Center, Los Angeles

90110

Prince of Songkla University, Hat Yai

90404

UCLA - David Geffen School of Medicine, Santa Monica

90603

The Oncology Institute of Hope and Innovation, Whittier

91010

City of Hope, Duarte

92037

Scripps, La Jolla

92868

University of California Irvine Division of Hematology-Oncology, Department of Medicine UC Irvine Health, Orange

95817

UC Davis, Sacramento

98101

Virginia Mason, Seattle

98109

Seattle Cancer Care Alliance, Seattle

06511

Yale Cancer Center, New Haven

02215

Beth Israel Deaconess Medical Center, Boston

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

03080

Seoul National University Hospital, Seoul

06591

The Catholic University of Korea Seoul St. Mary's Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

Sponsors
All Listed Sponsors
lead

Halozyme Therapeutics

INDUSTRY

NCT03267940 - Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma | Biotech Hunter | Biotech Hunter