NCT03267836View on ClinicalTrials.gov

Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma

PHASE1TerminatedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

January 10, 2018

Primary Completion Date

April 6, 2023

Study Completion Date

April 6, 2023

Conditions

MeningiomaMeningioma, Adult

Interventions

DRUG

Avelumab

-10mg/kg IV

RADIATION

Proton Therapy

-Proton therapy will start concurrently with the first dose of avelumab (up to 3 days before or after is permissible) and will be administered once daily during weekdays (Monday through Friday).

PROCEDURE

Surgery

-Standard of care

Trial Locations (1)

63110

Washington University School of Medicine, St Louis