120
Participants
Start Date
September 30, 2016
Primary Completion Date
March 11, 2020
Study Completion Date
March 11, 2020
DNA Analysis of Blood Sample
DNA analysis of the genes possibly involved in IBS.
Flexible sigmoidoscopy with colonic biopsies
Endoscopy of the subject's lower colon in which biopsies of the lining of the colon will be taken.
Small bowel and colonic gastrointestinal permeability
A validated scintigraphic method to measure gastric, small bowel and colonic transit will be used.
Stool sample analysis
Stool samples will be used to extract supernatants. These supernatants will be studied in using chamber set-up to determine barrier effects on T84 monolayers.
Mayo Clinic in Rochester, Rochester
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Mayo Clinic
OTHER