Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

September 11, 2017

Primary Completion Date

September 18, 2024

Study Completion Date

December 31, 2025

Conditions
HPV-Related CarcinomaHPV-Related Cervical CarcinomaHPV-Related Anal Squamous Cell CarcinomaHPV-Related Penile Squamous Cell CarcinomaHPV-Related Vulvar Squamous Cell Carcinoma
Interventions
BIOLOGICAL

TG4001

PhIb: Dose escalation PhII: Established RP2D for TG4001

DRUG

Avelumab

Anti PD-L1

Trial Locations (20)

32224

Mayo Clinic, Jacksonville

55905

Mayo Clinic, Rochester

Unknown

I.C.O. Paul Papin, Angers

CHU Besançon, Besançon

Hôpital Saint André - CHU de Bordeaux, Bordeaux

Hôpitaux Civils de Colmar - Hôpital Pasteur, Colmar

CLCC Georges-François Leclerc, Dijon

Centre Léon Bérard, Lyon

Hopital de la Timone, Marseille

Institut Curie, Paris

I.C.O. Gauducheau, Saint-Herblain

Centre Paul Strauss - ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg

Institut Claudius Regaud - IUCT - Oncopole, Toulouse

Institut Gustave Roussy, Villejuif

ICO Badalona - Hospital Germans Trias i Pujol, Badalona

Hospital Virgen de las Nieves, Granada

Fundación de Investigación biomédica H. 12 de Octubre, Madrid

Fundación de Investigación Biomédica Hospital Clínico San Carlos, Madrid

Hospital Virgen de La Victoria, Málaga

Hospital General de Valencia, Valencia

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

collaborator

EMD Serono Research & Development Institute, Inc.

INDUSTRY

collaborator

Pfizer

INDUSTRY

lead

Transgene

INDUSTRY