A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

September 18, 2017

Primary Completion Date

September 14, 2023

Study Completion Date

September 14, 2023

Conditions
Central Nervous System NeoplasmsMedulloblastoma
Interventions
DRUG

Pomalidomide

: Subjects will be administered pomalidomide on Days 1 to 21, followed by a 7-day rest period, of each 28-day treatment cycle and will continue treatment for up to 24 cycles or until disease progression, withdrawal of consent/assent or unresolved toxicities as described in the protocol.

DRUG

Pomalidomide

Pomalidomide will be provided as gelatin capsules and as an oral suspension. The starting dose will be 2.6 mg/m²/day, administered on Days 1 to 21, followed by a 7-day rest period, of each 28-day treatment cycle.

Trial Locations (22)

0

Local Institution - 201, Genova

8035

Local Institution - 302, Barcelona

13005

Local Institution - 103, Marseille

20133

Local Institution - 200, Milan

20892

Local Institution - 506, Bethesda

28009

Local Institution - 300, Madrid

31059

Local Institution - 106, Toulouse

32611

University Of Florida, Gainesville

46026

Local Institution - 301, Valencia

54511

Local Institution - 105, Vandœuvre-lès-Nancy

59020

Local Institution - 104, Lille

60611

Ann and Robert H Lurie Childrens Hospital of Chicago, Chicago

69008

Local Institution - 102, Lyon

75005

Local Institution - 100, Paris

77030

Texas Children's Hospital, Houston

94805

Local Institution - 101, Villejuif

94305-5750

Stanford University Cancer Center, Stanford

02115

Dana Farber Cancer Institute, Boston

00165

Local Institution - 202, Roma

LS7 4SA

Local Institution - 400, Leeds

WC1N 3JH

Local Institution - 403, London

SM2 5PT

Local Institution - 401, Sutton-Surrey

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY

NCT03257631 - A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors | Biotech Hunter | Biotech Hunter