Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD

NATerminatedINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

February 18, 2018

Primary Completion Date

August 10, 2022

Study Completion Date

August 17, 2022

Conditions
Acute Exacerbation of COPD
Interventions
DEVICE

Hemolung Respiratory Assist System

Treatment with a medical device called the Hemolung RAS. The Hemolung RAS includes three components: the Hemolung Controller, the Hemolung Cartridge, and the Hemolung Catheter. The intervention is use of the Hemolung RAS to provide partial lung support for acute hypercapnic lung failure by filtering carbon dioxide from venous blood using a central venous catheter through which venous blood is pumped at flows of 350-550 milliliters per minute to and from an external circuit containing a hollow fiber membrane blood gas exchanger (with heparin-coated fibers) integrated with a centrifugal pump.

DEVICE

Invasive mechanical ventilation

Lung support for acute lung failure applied with a mechanical ventilation device that uses positive pressure to mechanically inflate the lungs and facilitate exhalation via an endotracheal tube or tracheotomy.

Trial Locations (32)

10032

New York Presbyterian Hospital/Columbia University Medical Center, New York

11040

Northwell Health, New Hyde Park

15212

Allegheny General Hospital, Pittsburgh

18103

Lehigh Valley Health Network, Allentown

19104

Hospital of University of Pennsylvania, Philadelphia

19140

Temple University, Philadelphia

19718

Christiana Care Health System, Newark

22042

Inova Health Care Services, Falls Church

22903

University of Virginia Medical Center, Charlottesville

27710

Duke University Medical Center, Durham

30060

WellStar Kennestone Regional Medical Center, Marietta

32224

Mayo Clinic Jacksonville, Jacksonville

32610

University of Florida - Health Shands, Gainesville

37403

UT Erlanger, Chattanooga

38104

Memphis VA Medical Center, Memphis

40202

University of Louisville, Louisville

40502

Lexington VA Healthcare, Lexington

43210

Ohio State University, Columbus

44195

Cleveland Clinic, Cleveland

49504

Spectrum Health Hospitals, Grand Rapids

52242

University of Iowa, Iowa City

55407

Minneapolis Heart, Minneapolis

60611

Northwestern Memorial Hospital, Chicago

71103

LSU Health Shreveport, Shreveport

76508

Baylor Scott and White Memorial Hospital, Temple

77030

UT McGovern Medical School Memorial Hermann, Houston

80204

Denver Health Medical Center, Denver

95817

UC Davis Medical Group, Sacramento

02111

Tufts Medical Center, Boston

08902

Rutgers-Robert Wood Johnson University Hospital, New Brunswick

12208-3412

Albany Medical Center, Albany

02903

Rhode Island Hospital, Providence

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Alung Technologies

INDUSTRY