Liver Glycogen and Hypoglycemia in Humans

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

August 2, 2018

Primary Completion Date

May 31, 2028

Study Completion Date

May 31, 2028

Conditions
Hypoglycemia; Iatrogenic
Interventions
DRUG

Low Fructose

IV fructose (1.3 mg/kg/min)

DRUG

Saline

Saline given as a comparison to fructose.

DRUG

Somatostatin

IV infusion of somatostatin (60 ng/kg/min)

DRUG

Insulin

IV infusion of insulin between 20-60 mU/m2/min.

DRUG

Glucagon

IV glucagon (0.65 ng/kg/min).

DRUG

Dextrose solution

IV dextrose to clamp the plasma glucose at the desired level.

DRUG

High Fructose

IV-fructose (6.5 mg/kg/min)

Trial Locations (1)

45267

University of Cincinnati, Cincinnati

All Listed Sponsors
lead

Jason Winnick

OTHER