A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

October 9, 2017

Primary Completion Date

September 17, 2019

Study Completion Date

September 17, 2019

Conditions
Advanced Malignancies
Interventions
DRUG

INCAGN01949

In Phase 1, participants will receive INCAGN01949 administered intravenously (IV) at the protocol-defined dose according to cohort enrollment. In Phase 2, participants will receive INCAGN01949 administered IV at the recommended dose from Phase 1.

DRUG

Nivolumab

Nivolumab will be administered IV at the protocol-defined dose according to assigned treatment group.

DRUG

Ipilimumab

Ipilimumab will be administered IV at the protocol-defined dose according to assigned treatment group.

Trial Locations (15)

10016

New York University Clinical Cancer Center, New York

14642

University of Rochester Medical Center, Rochester

19111

Fox Chase Cancer Center, Philadelphia

28078

Carolina BioOncology Institute, Huntersville

33140

Mount Sinai Medical Center of Florida, Inc., Miami

37203

Sarah Cannon Research Institute, LLC (SCRI), Nashville

37232

Vanderbilt University Medical Center, Nashville

48109

University of Michigan, Ann Arbor

48201

Barbara Ann Karmanos Cancer Institute, Detroit

85258

Scottsdale Healthcare Hospitals DBA HonorHealth, Scottsdale

90025

The University of Alabama Birmingham (UAB), Birmingham

The Angeles Clinic and Research Institute, Los Angeles

97213

Providence Portland Medical Center, Portland

07601

John Theurer Cancer Center At Hackensack UMC, Hackensack

08901

Rutgers, The State University, New Brunswick

All Listed Sponsors
lead

Incyte Biosciences International Sàrl

INDUSTRY