Low Dose Aprepitant for Patients Receiving Carboplatin

PHASE2TerminatedINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

October 30, 2018

Primary Completion Date

February 11, 2021

Study Completion Date

February 11, 2021

Conditions
Chemotherapy-induced Nausea and Vomiting
Interventions
DRUG

Aprepitant 125 mg

Patient scheduled for the first cycle of carboplatin-based chemotherapy will be offered to receive low doses of aprepitant (125mg of oral aprepitant) or 115mg of fosaprepitant intravenously for prevention of chemotherapy-induced nausea and vomiting

DRUG

Fosaprepitant 115 MG

Patient scheduled for the first cycle of carboplatin-based chemotherapy will be offered to receive low doses of aprepitant (125mg of oral aprepitant) or 115mg of fosaprepitant intravenously for prevention of chemotherapy-induced nausea and vomiting

DRUG

Dexamethasone

Dexamethasone will be given as a part of standard CINV prophylaxis for patients receiving carboplatin-based chemotherapy, dosed at 20mg on day 1 of chemotherapy

DRUG

Ondansetron 16 MG

Ondansetron will be given as a part of standard CINV prophylaxis for patients receiving carboplatin-based chemotherapy, dosed at 16mg on day 1 of chemotherapy

Trial Locations (2)

10461

Jacobi Medical Center, The Bronx

Montefiore Medical Center, The Bronx

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Jacobi Medical Center

OTHER

lead

Albert Einstein College of Medicine

OTHER

NCT03237611 - Low Dose Aprepitant for Patients Receiving Carboplatin | Biotech Hunter | Biotech Hunter