Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

PHASE2CompletedINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

November 28, 2017

Primary Completion Date

April 17, 2024

Study Completion Date

April 17, 2024

Conditions
Neurofibromatosis Type 1Plexiform Neurofibroma
Interventions
DRUG

Binimetinib

Adult subjects (18 years and older) will receive binimetinib by mouth twice daily of 45mg/dose. Pediatric subjects (1-17 years of age) are being treated on the pediatric MTD established by a phase I study (NCT02285439).

Trial Locations (22)

10016

New York University Medical Center, New York

19096

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

20892

National Institute of Health - National Cancer Institute, Bethesda

21287

Johns Hopkins University, Baltimore

35294

University of Alabama at Birmingham, Birmingham

43205

Nationwide Children's Hospital, Columbus

43210

Ohio State University, Columbus

45229

Cinncinnati Children's Hospital Medical Center, Cincinnati

46202

Indiana University, Indianapolis

60611

Lurie Children's Hospital of Chicago, Chicago

60637

University of Chicago, Chicago

63110

Washington University School of Medicine, St Louis

84132

University of Utah, Salt Lake City

90027

Children's Hospital of Los Angeles, Los Angeles

90095

University of California at Los Angeles, Los Angeles

92123

University of California, San Diego - Rady Children's Hospital, San Diego

94153

University of California, San Francisco, San Francisco

94609

UCSF Benioff Children's Hospital Oakland, Oakland

97239

Oregon Health and Science University Hospital, Portland

98105

University of Washington - Seattle Children's Hospital, Seattle

02115

Boston Children's Hospital / Dana Farber Cancer Institute / Massachusetts General Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Array BioPharma

INDUSTRY

collaborator

Pacific Pediatric Neuro-Oncology Consortium

OTHER

lead

University of Alabama at Birmingham

OTHER