Ixazomib in the Prophylaxis of Chronic Graft-versus-host Disease.

Ixazomib capsules. Phase I: Starting dose of Ixazomib: 3.0 or 4.0 mg by day +1, +8 and +15. Phase II: Starting Dose of Ixazomib: Maximum tolerated dose from Phase I.

Tacrolimus at dose of 0.02 mg/kg/day and then 0.06 mg/kg/day.

Sirolimus oral solution. Standing 6 mg orally on day -5 and continued 4mg per day. This drugs should be slowly tapered starting 3 months posttransplant in order to stop them at 9 to 12 months posttransplant according to physician criteria.

Except antithymocyte globulin, cyclophosphamide or any T depletion protocol in vitro or in vivo.