A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms

PHASE1CompletedINTERVENTIONAL
Enrollment

277

Participants

Timeline

Start Date

August 18, 2017

Primary Completion Date

February 8, 2023

Study Completion Date

February 8, 2023

Conditions
Advanced Solid TumorsHematologic NeoplasmsOvarian CancerHER2-positive Advanced Solid TumorsNon Small Cell Lung CancerSmall-cell Lung CancerSquamous Cell Carcinoma of Head and NeckCholangiocarcinomaCervical CancerTNBC - Triple-Negative Breast Cancer
Interventions
BIOLOGICAL

tebotelimab 1 mg

1 mg IV every other week

BIOLOGICAL

tebotelimab 3 mg

3 mg IV every other week

BIOLOGICAL

tebotelimab 10 mg

10 mg IV every other week

BIOLOGICAL

tebotelimab 30 mg

30 mg IV every other week

BIOLOGICAL

tebotelimab 120 mg

120 mg IV every other week

BIOLOGICAL

tebotelimab 300 mg

300 mg IV every other wee

BIOLOGICAL

tebotelimab 400 mg

400 mg IV every other wee

BIOLOGICAL

tebotelimab 600 mg

600 mg IV every other week

BIOLOGICAL

tebotelimab 800 mg

800 mg IV every other week

BIOLOGICAL

tebotelimab 1200 mg

1200 mg IV every other week

BIOLOGICAL

margetuximab

15 mg/kg IV every 3 weeks

Trial Locations (40)

1407

"Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD, Sofia", Sofia

1632

"Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia", Sofia

2010

St Vincent's Hospital Sydney, Darlinghurst

2298

Calvary Mater Newcastle, Waratah

2500

Southern Medical Day Care Centre, Wollongong

3084

Austin Health Melbourne, Heidelberg

8000

"Complex Oncology Center - Burgas EOOD", Burgas

10330

King Chulalongkorn Memorial Hospital, Bangkok

15232

UPMC Hillman Cancer Center, Pittsburgh

18009

"Communal Nonprofit Enterprise Cherkassy Regional Oncology Dispensary of Cherkassy Regional Council", Cherkassy

19104

University of Pennsylvania, Abramson Cancer Center, Philadelphia

21029

Communal Nonprofit Enterprise Podillia Regional Center of Oncology of Vinnytsia Regional Council, Vinnytsia

21287

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

27710

Duke University Medical Center, Durham

28034

Hospital Ruber Internacional, Madrid

28050

START Madrid-CIOCC, Hospital HM Sanchinarro, Madrid

34232

Florida Cancer Specialists & Research Institute, Sarasota

37203

Sarah Cannon Research Institute, Nashville

40022

"Municipal Non-Profit Enterprise of Sumy Regional Council Sumy Regional Clinical Oncology Dispensary", Sumy

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

49102

"Communal Non-profit Enterprise City Clinical Hospital #4 of Dnipro City Council", Dnipro

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

60637

University of Chicago Medicine, Chicago

73104

Stephenson Cancer Center, The University of Oklahoma, Oklahoma City

76000

"Communal Nonprofit Enterprise Prykarpatsky Clinical Oncological Centre of Ivano-Frankivska Regional Council", Ivano-Frankivsk

77030

The University of Texas M.D. Anderson Cancer Center, Houston

85234

Banner MD Anderson Cancer Center, Gilbert

88000

"Communal Nonprofit Enterprise Central City Clinical Hospital of Uzhhorod City Council, City Oncology Center, State Higher Educational Institution <<Uzhhorod National University>>", Uzhhorod

90033

USC/Norris Comprehensive Cancer Center, Los Angeles

90095

UCLA Hematology & Oncology Clinic, Los Angeles

90110

Songklanagarind Hospital, Songkhla

92658

Hoag Memorial Hospital Presbyterian, Newport Beach

02215

Massachusetts General Hospital and Dana-Farber Cancer Institute, Boston

Unknown

Prince of Wales Hospital, Shatin

31-510

Pratia MCM Kraków, Krakow

05-410

BioVirtus Research Site Sp. Z o.o. / Biovirtus Centrum Medyczne, Józefów

02-034

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Państwowy Instytut Badawczy, Warsaw

02-781

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Państwowy Instytut Badawczy, Warsaw

60-693

Med-Polonia Sp. z o.o., Poznan

08035

Vall d'Hebron Institute of Oncology, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MacroGenics

INDUSTRY

NCT03219268 - A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms | Biotech Hunter | Biotech Hunter