NCT03206190View on ClinicalTrials.gov

The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

NARecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

July 1, 2018

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2031

Conditions
Hereditary Spastic ParaplegiaHereditary, Spastic Paraplegia, Autosomal Dominant
Interventions
OTHER

SPRS Score and clinical signs

Patients will clinically characterized by using the SPRS Score and the inventory V3

BEHAVIORAL

Cognition Testing using CANTAB

Patients will be tested using the CANTAB

DIAGNOSTIC_TEST

Lumbar Puncture and blood draw

Biomaterial will be collected (not obligate) to compare e.g. Nfl levels in serum and CSF

DIAGNOSTIC_TEST

MRI

MRI will be used to reveal presymptomatic brain morphology changes (not obligate)

DIAGNOSTIC_TEST

Electrophysiology

Electrophysiological tests will be used to characterize patients better.

DIAGNOSTIC_TEST

Testing functional performance

By using the 3 minute walk, 5 stair-climb test, and 10m walking test we will try to identify and measure subclinical progression prior to disease onset

DIAGNOSTIC_TEST

Non motor symptoms

By using a number of different tests we try to identify other non-motor symptoms which might manifest prior to disease onset.

Trial Locations (1)

72076

RECRUITING

University Hospital Tübingen, Center for Neurology, Tübingen

All Listed Sponsors
lead

University Hospital Tuebingen

OTHER