Study of Optimized Management of Nivolumab Based on Response in Patients With Advanced RCC (OMNIVORE Study)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

85

Participants

Timeline

Start Date

October 26, 2017

Primary Completion Date

November 30, 2021

Study Completion Date

December 28, 2025

Conditions
Renal Cancer
Interventions
DRUG

Ipilimumab

YERVOY is thought to work with the body's immune system to increase the activity of T cells and cause the body to attack cancer cells

DRUG

Nivolumab

Nivolumab binds to and blocks the activation of PD-1, an Ig superfamily transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs

Trial Locations (8)

27599

University of North Carolina at Chapel Hill, Chapel Hill

53792

Unviersity of Wisconsin Carbone Cancer Center, Madison

60637

University of Chicago Medical Center, Chicago

84112

University of Utah, Huntsman Cancer Center, Salt Lake City

92093

University of California, San Diego Moores Cancer Center, La Jolla

02115

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

02903

Lifespan Comprehensve Cancer Center, Providence

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Toni Choueiri, MD

OTHER

NCT03203473 - Study of Optimized Management of Nivolumab Based on Response in Patients With Advanced RCC (OMNIVORE Study) | Biotech Hunter | Biotech Hunter