IMA970A Plus CV8102 in Very Early, Early and Intermediate Stage Hepatocellular Carcinoma Patients

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

September 18, 2017

Primary Completion Date

December 20, 2019

Study Completion Date

December 20, 2019

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

IMA970A plus CV8102 and Cyclophosphamide

"Study treatment starts with a single intravenous infusion of 300mg/m2 Cyclophosphamide.~Three days later patients start vaccination therapy with IMA970A plus CV8102 Each vaccination consists of a dose of 6.80 milligrams (mg) IMA970A (containing approx. 400 micrograms \[µg\] of each individual peptide) followed by a dose of 50 µg CV8102. First IMA970A is injected intradermally (i.d.) and about 10 minutes later CV8102 is injected i.d. at the same vaccination site in close proximity. Patients will receive 4 vaccinations at weekly intervals followed by 5 vaccinations at 3-weekly intervals for a total duration of about 4.5 months."

Trial Locations (6)

2650

Universitair Ziekenhuis Antwerpen (UZA), Division of Gastroenterology and Hepatology, Edegem

31008

Universidad de Navarra (NAVAR), Internal Medicine, Pamplona

37024

Ospedale Sacro Cuore-Don Calabria U.O.C. Oncologica Medica, Negrar

72076

Universitätsklinik für Allgemeine, Viszeral- und Transplantationschirurgie, Tübingen

80131

"Istituto Nazionale Tumori Pascale (INTNA)", Napoli

B152TT

The University of Birmingham, School of Immunity and Infection, College of Medical and Dental Science (BHAM), Birmingham

Sponsors
All Listed Sponsors
collaborator

Immatics Biotechnologies GmbH

INDUSTRY

collaborator

CureVac

INDUSTRY

collaborator

European Commission

OTHER

lead

National Cancer Institute, Naples

OTHER