A Trial Evaluating the Efficacy and Safety of Prophylactic Administration of Concizumab in Haemophilia A and B Patients With Inhibitors

PHASE2CompletedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

August 10, 2017

Primary Completion Date

September 19, 2018

Study Completion Date

January 31, 2020

Conditions
Congenital Bleeding DisorderHaemophilia A With InhibitorsHaemophilia B With Inhibitors
Interventions
DRUG

Concizumab

A loading dose of 0.5 mg/kg will be given as the first dose, followed by 0.15 mg/kg (with potential stepwise dose escalation to 0.25 mg/kg) administered daily s.c. (subcutaneously, under the skin). Treatment duration is 24 weeks in the main trial, and up to 52 weeks in the extension phase

DRUG

Eptacog alfa

A single dose of 90 μg/kg eptacog alfa one week after dosing with concizumab. On-demand treatment during bleeding episodes in both treatment arms

Trial Locations (22)

1090

Novo Nordisk Investigational Site, Vienna

8200

Novo Nordisk Investigational Site, Århus N

10450

Novo Nordisk Investigational Site, Georgetown, Penang

20124

Novo Nordisk Investigational Site, Milan

28046

Novo Nordisk Investigational Site, Madrid

41013

Novo Nordisk Investigational Site, Seville

46260

Novo Nordisk Investigational Site, Indianapolis

50134

Novo Nordisk Investigational Site, Florence

52242

Novo Nordisk Investigational Site, Iowa City

52621

Novo Nordisk Investigational Site, Tel Litwinsky

79044

Novo Nordisk Investigational Site, Lviv

88586

Novo Nordisk Investigational Site, Kota Kinabalu

90027

Novo Nordisk Investigational Site, Los Angeles

M5B 1X1

Novo Nordisk Investigational Site, Toronto

10 000

Novo Nordisk Investigational Site, Zagreb

GR-11527

Novo Nordisk Investigational Site, Athens

466-8560

Novo Nordisk Investigational Site, Aichi

634-8522

Novo Nordisk Investigational Site, Nara

167-0035

Novo Nordisk Investigational Site, Tokyo

171 64

Novo Nordisk Investigational Site, Solna

SE1 7EH

Novo Nordisk Investigational Site, London

S10 2JF

Novo Nordisk Investigational Site, Sheffield

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY

NCT03196284 - A Trial Evaluating the Efficacy and Safety of Prophylactic Administration of Concizumab in Haemophilia A and B Patients With Inhibitors | Biotech Hunter | Biotech Hunter