First-in-human Study of ATR Inhibitor BAY1895344 in Patients With Advanced Solid Tumors and Lymphomas

PHASE1CompletedINTERVENTIONAL
Enrollment

229

Participants

Timeline

Start Date

July 6, 2017

Primary Completion Date

December 2, 2022

Study Completion Date

September 13, 2023

Conditions
Advanced Solid TumorNon-Hodgkin's LymphomaMantle Cell Lymphoma
Interventions
DRUG

Elimusertib (BAY1895344)

Solution or tablet, oral, to be administered until evidence of tumor progression, unacceptable toxicity, consent withdrawal, or withdrawal from the study at the discretion of the investigator.

Trial Locations (29)

1009

Kantonsspital St. Gallen, Sankt Gallen

1205

Hôpital Cantonal Universitaire de Genève, Geneva

6500

Oncology Institute of Southern Switzerland, Bellinzona

10021

Weill Cornell Medical College, New York

19107

Jefferson Medical College, Philadelphia

22031

Fairfax-Northern Virginia Hematology/Oncology, PC, Fairfax

30322

Emory University, Atlanta

33612

H. Lee Moffitt Cancer Center & Research Institute, Tampa

44106

University Hospitals Cleveland Medical Center, Cleveland

44718

Gabrail Cancer Center, Canton

78217

Texas Oncology- San Antonio Northeast, San Antonio

84112

University of Utah - Oncology, Salt Lake City

91010

City of Hope National Medical Center, Duarte

97401

US Oncology / Eugene, Eugene

100142

Beijing Cancer Hospital, Beijing

119228

National University Hospital, Singapore

168583

National Cancer Center Singapore, Singapore

02114-2696

Massachusetts General Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

77030-4009

University of Texas MD Anderson Cancer Center, Houston

T6G 1Z2

Cross Cancer Institute, Edmonton

K1H 8L6

OHRI - The Ottawa Hospital, Ottawa

G1J 1Z4

Integrated Cancer Center of the CHU de Québec, Québec

277-8577

National Cancer Center Hospital East, Kashiwa

411-8777

Shizuoka Cancer Center, Sunto

104-0045

National Cancer Center Hospital, Chuo-ku

CF14 2TL

Velindre Hospital, Cardiff

SM2 5PT

Royal Marsden NHS Trust (Surrey), Sutton

NE7 7DN

Freeman Hospital, Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY