Radiation and Immune Checkpoints Blockade in Metastatic NSCLC (BMS # CA209-632)

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

October 9, 2017

Primary Completion Date

March 11, 2022

Study Completion Date

March 11, 2022

Conditions
Non Small Cell Lung Cancer Metastatic
Interventions
DRUG

Ipilimumab

Ipilimumab (3mg/kg) is given concurrently (+/- 24hrs from first RT dose) with radiation therapy on Day 1 of the study. On day 22 the combined treatment of ipilimumab plus nivolumab will start (nivolumab 240mg q 2 weeks, ipilimumab 1mg/kg q 6 weeks), and administered until evidence of progression.

DRUG

Nivolumab

On day 22 the combined treatment of ipilimumab plus nivolumab will start (nivolumab 240mg q 2 weeks, ipilimumab 1mg/kg q 6 weeks), and administered until evidence of progression.

RADIATION

Radiation therapy

Ipilimumab (3mg/kg) is given concurrently (+/- 24hrs from first RT dose) with radiation therapy on Day 1 of the study.

Trial Locations (1)

10065

Weill Cornell Medicine, New York

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Weill Medical College of Cornell University

OTHER

NCT03168464 - Radiation and Immune Checkpoints Blockade in Metastatic NSCLC (BMS # CA209-632) | Biotech Hunter | Biotech Hunter