UCDCC#270: Avelumab and Stereotactic Ablative Radiotherapy in Non-responding and Progressing NSCLC Patients

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

May 17, 2017

Primary Completion Date

April 9, 2020

Study Completion Date

June 24, 2020

Conditions
Metastatic Non-small Cell Lung Cancer (NSCLC)
Interventions
DRUG

Avelumab

Avelumab: 10 mg/kg administered by IV infusion q2w (1 cycle = 14 \[±2\] days).

RADIATION

Stereotactic ablative radiotherapy (SAR)

SAR: the prescription dose will be 50 Gy over 5 fractions of 10 Gy each on an every 2 day basis (i.e., 2-3 treatments per week, with a minimum of 40 hours and a maximum of 96 hours between treatments) and completed within 1.5-2 weeks. SAR treatment will not be repeated.

Trial Locations (1)

95817

UC Davis, Sacramento

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

EMD Serono

INDUSTRY

lead

Megan Daly, MD

OTHER

NCT03158883 - UCDCC#270: Avelumab and Stereotactic Ablative Radiotherapy in Non-responding and Progressing NSCLC Patients | Biotech Hunter | Biotech Hunter