Taper Or Abrupt Steroid Stop: TOASSTtrial

PHASE4RecruitingINTERVENTIONAL
Enrollment

573

Participants

Timeline

Start Date

May 31, 2017

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Inflammatory DisorderAutoimmune
Interventions
DRUG

Prednisone

The control intervention (standard treatment) consists of prednisone treatment in decreasing doses, starting with 7.5 mg q.d. and reducing the dose every 7 days, such that prednisone treatment is stopped after a total of 4 weeks.

OTHER

Placebo Arm

The experimental intervention consists of stopping glucocorticoid treatment abruptly and administering matching placebo over 4 weeks.

Trial Locations (15)

1205

RECRUITING

Geneva University Hospitals, Geneva

3010

RECRUITING

Department of Rheumatology, Immunology, and Allergology, Inselspital, Bern

4031

RECRUITING

Endocrinology/Diabetology/Metabolism; University Hospital Basel, Basel

4410

RECRUITING

Center for Primary Health Care,University of Basel, Kantonsspital Baselland, Liestal

RECRUITING

Internal Medicine, Kantonsspital Baselland/Liestal, Liestal

4600

RECRUITING

Stoffwechselzentrum, Kantonsspital Olten, Olten

5001

RECRUITING

Departement of Internal Medicine, Kantonsspital Aarau, Aarau

5404

RECRUITING

Kantonsspital Baden, Baden

8091

RECRUITING

Dept. of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Zurich

8180

RECRUITING

Division of Gastroenterology, Spital Bülach AG, Bülach

8501

RECRUITING

Kantonsspital Frauenfeld, Frauenfeld

8596

RECRUITING

Department of Internal Medicine, Kantonsspital Münsterlingen, Münsterlingen

9007

RECRUITING

Department of Internal Medicine, Kantonsspital St. Gallen, Sankt Gallen

97080

RECRUITING

University Hospital Würzburg, Würzburg

Unknown

RECRUITING

University Hospital Frankfurt, Frankfurt

All Listed Sponsors
collaborator

Kantonsspital Baselland Bruderholz

OTHER

collaborator

Swiss National Science Foundation

OTHER

collaborator

HEMMI Stiftung Switzerland

UNKNOWN

lead

University Hospital, Basel, Switzerland

OTHER