Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

145

Participants

Timeline

Start Date

April 25, 2017

Primary Completion Date

November 9, 2021

Study Completion Date

November 9, 2021

Conditions
Advanced MalignanciesMetastatic Cancer
Interventions
DRUG

INCAGN01876

In Phase 1 participants will receive INCAGN01876 administered intravenously (IV) at the protocol-defined dose according to cohort enrollment. In Phase 2, participants will be administered IV study drug at the recommended dose from Phase 1 ().

DRUG

Nivolumab

Nivolumab will be administered IV at the protocol-defined dose according to assigned treatment group.

DRUG

Ipilimumab

Ipilimumab will be administered IV at the protocol-defined dose according to assigned treatment group.

Trial Locations (38)

1000

Institut Jules Bordet, Brussels

1020

CHU Brugmann, Brussels

1200

Cliniques Universitaires Saint-Luc, Brussels

2148

Blacktown Cancer and Haematology Centre, Blacktown

Scientia Clinical Research, Randwick

2610

Saint Augustinus Hospital, Antwerp

3084

Austin Hospital, Heidelberg

4120

Greenslopes Private Hospital, Brisbane

6000

Mi Kryviy Rih Center of Dnipropetrovsk Regional Council, Charleroi

6009

Linear Clinical Research, Perth

6800

CHA Centre Hospitalier de l'Ardenne, Libramont

8500

AZ Groeninge, Kortrijk

10065

Memorial Sloan Kettering Cancer, New York

14004

Hospital Reina Sophia, Córdoba

15232

University of Pittsburgh, UPMC Cancer Pavilion, Pittsburgh

19111

Fox Chase Cancer Center, Philadelphia

27599

The University of North Carolina at Chapel Hill, Chapel Hill

28034

University Hospital Ramon y Cajal, Madrid

28041

Hospital Universitario Doce de Octubre, Madrid

28050

Hospital HM Sanchinarro, Madrid

31008

Clinica Universidad De Navarra (CUN), Pamplona

32610

University of Florida, Gainesville

37201

Washington University - Siteman Cancer Center, St Louis

Tennessee Oncology, Sarah Cannon Research Institute, Nashville

Ghent University Hospital, Ghent

41015

Hospital Universitario Virgen Del Rocio, Seville

48201

Karmanos Cancer Institute, Detroit

73104

University of Oklahoma, Sarah Cannon Research Institute, Oklahoma City

75230

BUMC Mary Crowley Cancer Research Centers, Dallas

77030

MD Anderson, Houston

90025

The Angeles Clinic and Research Institute, Los Angeles

97213

Providance Portland Medical Center, Portland

98109

Seattle Cancer Care Alliance, Seattle

07601

Hackensack University Medical Center, Hackensack

08036

Hospital Clinic I Provincial, Barcelona

Hospital Clinico y Provincial de Barcelona, Barcelona

08916

Institut Catala D'Oncologia-Badalona, Barcelona

Unknown

Hospital Vall de Hebron, Barcelona

All Listed Sponsors
lead

Incyte Biosciences International Sàrl

INDUSTRY