Phase 2 Study of Ruxolitinib Versus Anagrelide in Subjects With Essential Thrombocythemia Who Are Resistant to or Intolerant of Hydroxyurea (RESET-272)

PHASE2TerminatedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

November 14, 2017

Primary Completion Date

August 3, 2020

Study Completion Date

August 3, 2020

Conditions
MPN (Myeloproliferative Neoplasms)
Interventions
DRUG

Ruxolitinib

Ruxolitinib administered orally twice daily (BID) at the protocol-defined starting dose.

DRUG

Anagrelide

Anagrelide administered orally at a starting dose of 1 mg BID.

DRUG

Placebo

Anagrelide-placebo administered orally BID

DRUG

Placebo

Ruxolitinib-placebo administered orally BID.

Trial Locations (26)

10032

Columbia Weill Cornell Cancer Centers - Herbert Irving Comprehensive Cancer Center (HICCC), New York

10467

Montefiore Medical Center, The Bronx

17822

Geisinger - Knapper Clinic, Danville

21229

St. Agnes Hospital, Baltimore

27518

Waverly Hem Onc, Cary

27858

Vidant Medical Center, Greenville

31794

Tift Regional, Tifton

33880

Bond Clinic, PA, Winter Haven

44718

Gabrail Cancer Center- Canton Facility, Canton

57201

Prairie Lakes Health Care System Inc., Watertown

60076

North Shore Cancer Research Association-Skokie, Skokie

60540

Edward Cancer Center, Naperville

62702

Southern Illinois University, Springfield

63110

Washington University School of Medicine, St Louis

70601

Clinical Trials of SWLA LLC, Lake Charles

73109

INTEGRIS Southwest Medical Center, Oklahoma City

73142

INTEGRIS Cancer Institute Proton Campus, Oklahoma City

77401

Renovatio Clinical, The Woodlands

85054

Mayo Clinic, Phoenix

90033

University of Southern California, Los Angeles

90603

Innovative Clinical Research Institute, Whittier

90813

Pacific Shores Medical Group, Long Beach

92501

Compassionate Cancer Care Medical Group, Riverside

93030

Ventura County Hematology-Oncology Specialists, Oxnard

97227

Kaiser Permanente Northwest, Portland

07960

Summit Medical Group, Morristown

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY