Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

40 mg/m\^2 IVBP daily for day -5 (5 days before stem cell infusion) through Day -2

targeting a 4800μM/min/ day from day -5 through day -2

0.5 mg/kg IV on day -3, and 2 mg/kg on days -2 and day -1

dose of 3Gy on days -3, -2 and -1

Day 0 according to BMT unit policy

The starting dose is at 0.03 mg/kg/day IV continuous infusion over 24 hr from 4 PM on day -2. Dose will be adjusted to target trough levels of 5-15 ng/mL. More information is available in the protocol document.

5mg/m\^2 on Day 1, 5 mg/m\^2 on Days 3, 6 and 11