Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease

0.5 mg/kg IV on day -9, and 2 mg/kg on days -8 and day -7

30 mg/m2 IVPB daily for day -6 (6 days before stem cell infusion) through day -2

14.5 mg/kg IV on days -6 and -5 and 50 mg/kg/d on days +3 and +4

3 Gy on day -1

Stem cell product infused according to BMT unit policy on day 0.

loading dose of 15 mg followed by 5 mg per day on day +5

1 g every 8 h (until day 35) will be started on day 5