Phase 1b/2a Study of ABI-H0731 in Patients With Chronic Hepatitis B

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

June 15, 2017

Primary Completion Date

March 31, 2018

Study Completion Date

June 12, 2018

Conditions
Chronic Hepatitis B
Interventions
DRUG

ABI-H0731

A novel HBV core protein allosteric modifier (CpAM) which is being developed as a potential therapeutic advance for CHB patients

DRUG

Placebo for ABI-H0731

Sugar pill manufactured to mimic the ABI-H0731 tablet

DRUG

Entecavir

An antiviral medication used in the treatment of hepatitis B virus infection

DRUG

Tenofovir Disoproxil Fumarate

An antiviral medication used in the treatment of hepatitis B virus infection

DRUG

Pegasys

Used to treat adults with chronic hepatitis B virus who show signs of liver damage

Trial Locations (14)

Unknown

Monash University, Clayton

St. Vincent's Hospital, Fitzroy

The Alfred Hospital, Melbourne

Linear Clinical Research, Nedlands

University of Hong Kong, Hong Kong

Hallym University, Chuncheon

CHA Bundang Medical Center, Gyeonggi-do

Asan Medical Center, Seoul

Severance Hospital, Yonsei University, Seoul

Keelung Chang Gung Memorial Hospital, Keelung

National Taiwan University Hospital, Taipei

King's College Hospital, London

Royal Free Hospital NHS Foundation Trust, London

Royal London Hospital, London

Sponsors
All Listed Sponsors
lead

Assembly Biosciences

INDUSTRY

NCT03109730 - Phase 1b/2a Study of ABI-H0731 in Patients With Chronic Hepatitis B | Biotech Hunter | Biotech Hunter