Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma

PHASE2TerminatedINTERVENTIONAL
Enrollment

210

Participants

Timeline

Start Date

June 22, 2017

Primary Completion Date

August 22, 2025

Study Completion Date

August 22, 2025

Conditions
Cervical Carcinoma
Interventions
BIOLOGICAL

LN-145

A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes.

BIOLOGICAL

LN-145 + pembrolizumab

A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. The first dose of anti-PD-1 immunotherapy will be administered following tumor resection.

Trial Locations (43)

1105

Academisch Medisch Centrum, Amsterdam

14263

Roswell Park Cancer Institute, Buffalo

15224

Allegheny Health, Pittsburgh

15232

UPMC Cancer Center, Pittsburgh

20141

Istituto Europeo di Oncologia, Miano

22908

University of Virginia, Charlottesville

28007

Hospital General Universitario Gregorio Marañon, Madrid

28050

Hospital Universitario Madrid Sanchinarro, Madrid

31008

Clínica Universidad de Navarra, Pamplona

32806

University of Florida Health Cancer Center, Orlando

33136

Sylvester Comprehensive Cancer Center, Miami

33612

University of South Florida H. Lee Moffitt Cancer Center and Research Institute, Tampa

40202

James Graham Brown Cancer Center, Louisville

43210

The Ohio State University Comprehensive Cancer Center, Columbus

44195

Cleveland Clinic, Cleveland

48201

Karmanos Cancer Institute, Detroit

53225

Medical College of Wisconsin, Milwaukee

57105

Avera Medical Group Oncology, Sioux Falls

60637

University of Chicago, Chicago

69008

Centre Léon Bérard, Lyon

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70112

LSU Health Sciences Center, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

MD Anderson Cancer Center, Houston

85013

St. Joseph's Hospital and Medical Center Center For Women's Health, Phoenix

90033

University of Southern California, Los Angeles

91054

Universitätsklinikum Erlangen, Erlangen

92093

University of California San Diego, San Diego

94805

Gustave Roussy Cancer Campus, Villejuif

30912-0003

Augusta University, Augusta

21287-0013

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

02215

Dana Farber Cancer Institute, Boston

07103

Rutgers University, Newark

01307

Universitätsklinikum Carl Gustav Carus, Dresden

08035

Hospital Universitari Vall d'Hebrón, Barcelona

08908

Institut Català d'Oncologia, Barcelona

CH-3010

Inselspital, Bern

Unknown

Centre Hospitalier Universitaire Vaudois Lausanne - Centre Pluridisciplinaire d'Oncologie, Lausanne

BS2 8ED

Bristol Haematology and Oncology Centre, Bristol

W1G 6AD

Sarah Cannon Research Institute London, London

W1G 6BW

University College London Hospitals NHS Foundation Trust, London

G12 0YN

NHS Greater Glasgow and Clyde, Glasgow

SE1 9RT

Guy's & St.Thomas NHS Foundation Trust, London

Sponsors
All Listed Sponsors
lead

Iovance Biotherapeutics, Inc.

INDUSTRY

NCT03108495 - Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma | Biotech Hunter | Biotech Hunter