Co-crystal E-58425 vs Tramadol and Celecoxib for Moderate to Severe Acute Pain After Bunionectomy. Phase III Clinical Trial.

Co-crystal E-58425 (Tramadol/Celecoxib): Two immediate release oral over-encapsulated tablets of 100 mg, every 12 hours for 48 hours.

Tramadol: One immediate release oral over-encapsulated tablet of 50 mg, every 6 hours for 48 hours.

Celecoxib: One immediate release oral over-encapsulated capsule of 100 mg, every 12 hours for 48 hours.

Placebo 100 mg or 200 mg oral over-encapsulated tablets every 6 hours for 48 hours.