Study to Assess Safety and Efficacy of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren's Syndrome

PHASE2CompletedINTERVENTIONAL
Enrollment

152

Participants

Timeline

Start Date

May 1, 2017

Primary Completion Date

January 10, 2019

Study Completion Date

October 2, 2019

Conditions
Sjogren's Syndrome
Interventions
DRUG

Lanraplenib

1 x 30 mg tablet administered orally once daily

DRUG

Filgotinib

1 x 200 mg tablet administered orally once daily

DRUG

Tirabrutinib

1 x 40 mg tablet administered orally once daily

DRUG

Lanraplenib placebo

1 x tablet administered orally once daily

DRUG

Filgotinib placebo

1 x tablet administered orally once daily

DRUG

Tirabrutinib placebo

1 x tablet administered orally once daily

Trial Locations (53)

6800

Hospital De Merida, Mérida

16635

Altoona Center for Clinical Research, Duncansville

18015

East Penn Rheumatology Associates, P.C., Bethlehem

19610

Clinical Research Center of Reading, LLC, Wyomissing

23320

The Center for Arthritis and Rheumatic Diseases, PC, Chesapeake

28144

PMG Research of Salisbury, Salisbury

28204

Joint and Muscle Research Institute, Charlotte

28451

Cape Fear Arthritis Care, PLLC, Leland

28942

Hospital Universitario de Fuenlabrada, Fuenlabrada

29009

Hospital Regional Universitario de Malaga, Málaga

30046

North Georgia Rheumatology Group, PC, Lawrenceville

32713

Omega Research Consultants LLC, DeBary

33309

Center for Rheumatology Immunology and Arthritis, Fort Lauderdale

33324

IRIS Research and Development, LLC, Plantation

33765

Clinical Research of West Florida, Inc., Clearwater

34668

Suncoast Clinical Research, Inc., New Port Richey

37007

Hospital Clinico Universitario de Salamanca, San Vicente

37421

ClinSearch, Chattanooga

38119

Ramesh C. Gupta, MD, Memphis

38801

North Mississippi Medical Clinics, Inc. - Clinical Research, Tupelo

41010

Hospital Quironsalud Infanta Luisa, Seville

42701

Center for Arthritis & Osteoporosis, Elizabethtown

48910

June DO, PC, Lansing

62703

Springfield Clinic, Springfield

63117

Clayton Medical Associates, St Louis

68516

Physician Research Collaboration, LLC, Lincoln

75024

Trinity Universal Research Associates, Plano

75150

Southwest Rheumatology Research, Mesquite

76710

Arthritis & Osteoporosis Clinic, Waco

77034

Accurate Clinical Research Inc., Houston

77701

Diagnostic Group Integrated Healthcare System, Pllc, Beaumont

80230

Denver Arthritis Clinic, Denver

84041

Wasatch Peak Family Practice, Layton

85032

AARR Arizona Arthritis & Rheumatology Research, Phoenix

85202

AARR Arizona Arthritis & Rheumatology Research, Mesa

87102

Albuquerque Clinical Trials, Albuquerque

91723

Medvin Clinical Research, Covina

91786

Inland Rheumatology Clinical Trials, Inc., Upland

99204

Arthritis Northwest, Spokane

82-300

Centrum Kliniczno-Badawcze, Elblag

64-000

Intermedius, Kościan

60-733

Centrum Badan Klinicznych S.C, Poznan

61-113

Ai Centrum Medyczne, Poznan

03-921

Centrum Medyczne Amed Warszawa Targowek, Warsaw

52-416

Centrum Medyczne Oporow, Wroclaw

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

03203

Hospital General Universitario De Elche, Elche

08208

Corporacio Sanitaria Parc Taulí de Sabadell, Sabadell

DN2 5LT

Doncaster Royal Infirmary, Doncaster

EX4 2XU

Western General Hospital, Edinburgh

CM20 1QX

Princess Alexandra Hospital, Harlow

SN3 6BB

Great Western Hospital, Swindon

WA5 1QG

Warrington Hospital, Warrington

Sponsors
All Listed Sponsors
collaborator

Galapagos NV

INDUSTRY

collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Gilead Sciences

INDUSTRY