Pembrolizumab With Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients With Chest Wall Disease

PHASE2CompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

September 2, 2017

Primary Completion Date

November 30, 2024

Study Completion Date

November 30, 2024

Conditions
Breast CancerChest Wall Disease
Interventions
BIOLOGICAL

Pembrolizumab

200 mg Given IV

DRUG

Carboplatin

Arm A: AUC 5 IV every 3 weeks Arm B: AUC 5 IV every 3 weeks

BIOLOGICAL

Trastuzumab

For HER2+ patients: IV every 3 weeks using standard approved dosing

Trial Locations (7)

15232

University of Pittsburgh Cancer Institute, Pittsburgh

20007

Georgetown University Hospital, Washington D.C.

37232

Vanderbilt University/Ingram Cancer Center, Nashville

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

60637

University of Chicago Comprehensive Cancer Center, Chicago

94143

University of California, San Francisco, San Francisco

02114

Massachusetts General Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Mayo Clinic

OTHER

collaborator

Johns Hopkins University

OTHER

collaborator

Translational Breast Cancer Research Consortium

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Laura Huppert, MD, BA

OTHER

NCT03095352 - Pembrolizumab With Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients With Chest Wall Disease | Biotech Hunter | Biotech Hunter