Ceritinib + Trametinib in Patients With Advanced ALK-Positive Non-Small Cell Lung Cancer (NSCLC)

PHASE1TerminatedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

September 9, 2017

Primary Completion Date

April 30, 2022

Study Completion Date

April 30, 2022

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Ceritinib

"ALK tyrosine inhibitor, 300 mg - 450 mg PO daily.~Phase I dose escalation:~1. Ceritinib 300mg~2. Ceritinib 450mg~3. Ceritinib 450mg~The Phase II doses will be determined by Phase I dose escalation study"

DRUG

Trametinib

"MEK kinase inhibitor, 1.5 mg - 2.0 mg PO daily.~Phase I dose escalation:~1. Trametinib 1.5mg~2. Trametinib 1.5mg~3. Trametinib 2.0mg~The Phase II doses will be determined by Phase I dose escalation study"

Trial Locations (2)

94143

University of California, San Francisco, San Francisco

95616

University of California, Davis, Davis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

collaborator

University of California, Davis

OTHER

lead

University of California, San Francisco

OTHER